Adolescents and young adults with cancer: the clinical course of COVID-19 infections

POCC Consortium

doi:10.1093/jnci/djae085

Adolescents and young adults with cancer: the clinical course of COVID-19 infections

POCC Consortium

Research output: Contribution to journal › Article › peer-review

Abstract

Adolescents and young adults (ie, individuals aged 15-39 years, known as AYAs) with cancer face unique vulnerabilities yet remain underrepresented in clinical trials, including adult registries of COVID-19 in cancer (AYAs: 8%-12%). We used the Pediatric Oncology COVID-19 Case Report to examine the clinical course of COVID-19 among AYAs with cancer. The Pediatric Oncology COVID-19 Case Report collects deidentified clinical and sociodemographic data regarding individuals aged from birth to 39 years with cancer (37%) and COVID-19 from more than 100 institutions. Between April 1, 2020, and November 28, 2023, 191 older AYAs (individuals 22-39 years of age) and 640 younger AYAs (individuals 15-21 years of age) were captured. Older AYAs were less often hospitalized (P < .001), admitted to the intensive care unit (P = .02), and required respiratory support (P = .057). In multivariable analyses, older AYAs faced 80% lower odds of intensive care unit admission but 2.3-times greater odds of changes to cancer-directed therapy. Unvaccinated patients had 5.4-times higher odds of intensive care unit admission. Among AYAs with cancer, the COVID-19 course varies by age. These findings can inform oncology teams directing COVID-19 management and prevention in AYA patients with cancer.

Original language	English (US)
Pages (from-to)	1366-1373
Number of pages	8
Journal	Journal of the National Cancer Institute
Volume	116
Issue number	8
DOIs	https://doi.org/10.1093/jnci/djae085
State	Published - Aug 1 2024

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1093/jnci/djae085

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@article{44e63e24e9d44f3c9a88e40061fc0810,

title = "Adolescents and young adults with cancer: the clinical course of COVID-19 infections",

abstract = "Adolescents and young adults (ie, individuals aged 15-39 years, known as AYAs) with cancer face unique vulnerabilities yet remain underrepresented in clinical trials, including adult registries of COVID-19 in cancer (AYAs: 8%-12%). We used the Pediatric Oncology COVID-19 Case Report to examine the clinical course of COVID-19 among AYAs with cancer. The Pediatric Oncology COVID-19 Case Report collects deidentified clinical and sociodemographic data regarding individuals aged from birth to 39 years with cancer (37%) and COVID-19 from more than 100 institutions. Between April 1, 2020, and November 28, 2023, 191 older AYAs (individuals 22-39 years of age) and 640 younger AYAs (individuals 15-21 years of age) were captured. Older AYAs were less often hospitalized (P < .001), admitted to the intensive care unit (P = .02), and required respiratory support (P = .057). In multivariable analyses, older AYAs faced 80% lower odds of intensive care unit admission but 2.3-times greater odds of changes to cancer-directed therapy. Unvaccinated patients had 5.4-times higher odds of intensive care unit admission. Among AYAs with cancer, the COVID-19 course varies by age. These findings can inform oncology teams directing COVID-19 management and prevention in AYA patients with cancer.",

author = "{POCC Consortium} and Wolfson, {Julie A.} and Davis, {Elizabeth S.} and Aniket Saha and Isaac Martinez and David McCall and Prachi Kothari and Julienne Brackett and Dickens, {David S.} and Kahn, {Alissa R.} and Carla Schwalm and Archana Sharma and Joshua Richman and Branko Cuglievan and Smita Bhatia and Chen Dai and Levine, {Jennifer M.} and Johnston, {Emily E.} and Catherine Aftandilian and Agrawal, {Anurag K.} and {De Angulo}, Guillermo and Paula Aristizabal and Kayleen Bailey and Bardwell, {Jenna K.} and Becton, {David L.} and Bemrich-Stolz, {Christina J.} and Boal, {Lauren H.} and Boston, {Catherine W.H.} and Bradfield, {Scott M.} and Caywood, {Emi H.} and Alexander Chou and Cohn, {Shannon M.} and Colace, {Susan I.} and Coven, {Scott L.} and Cramer, {Stuart L.} and Dargart, {Jamie L.} and Doured Daghistani and Aditi Dhir and Anca Dumitriu and Eslin, {Don E.} and Esquilin, {Jose M.} and Feinberg, {Shari L.} and Asmaa Ferdjallah and Fernandez, {Karen S.} and Jason Fixler and Foley, {Jessica M.} and Gampel, {Bradley H.} and Glasser, {Chana L.} and Goodman, {Jessica F.} and Moran Gotesman and Brandon Hayes-Lattin",

year = "2024",

month = aug,

day = "1",

doi = "10.1093/jnci/djae085",

language = "English (US)",

volume = "116",

pages = "1366--1373",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - Adolescents and young adults with cancer

T2 - the clinical course of COVID-19 infections

AU - POCC Consortium

AU - Wolfson, Julie A.

AU - Davis, Elizabeth S.

AU - Saha, Aniket

AU - Martinez, Isaac

AU - McCall, David

AU - Kothari, Prachi

AU - Brackett, Julienne

AU - Dickens, David S.

AU - Kahn, Alissa R.

AU - Schwalm, Carla

AU - Sharma, Archana

AU - Richman, Joshua

AU - Cuglievan, Branko

AU - Bhatia, Smita

AU - Dai, Chen

AU - Levine, Jennifer M.

AU - Johnston, Emily E.

AU - Aftandilian, Catherine

AU - Agrawal, Anurag K.

AU - De Angulo, Guillermo

AU - Aristizabal, Paula

AU - Bailey, Kayleen

AU - Bardwell, Jenna K.

AU - Becton, David L.

AU - Bemrich-Stolz, Christina J.

AU - Boal, Lauren H.

AU - Boston, Catherine W.H.

AU - Bradfield, Scott M.

AU - Caywood, Emi H.

AU - Chou, Alexander

AU - Cohn, Shannon M.

AU - Colace, Susan I.

AU - Coven, Scott L.

AU - Cramer, Stuart L.

AU - Dargart, Jamie L.

AU - Daghistani, Doured

AU - Dhir, Aditi

AU - Dumitriu, Anca

AU - Eslin, Don E.

AU - Esquilin, Jose M.

AU - Feinberg, Shari L.

AU - Ferdjallah, Asmaa

AU - Fernandez, Karen S.

AU - Fixler, Jason

AU - Foley, Jessica M.

AU - Gampel, Bradley H.

AU - Glasser, Chana L.

AU - Goodman, Jessica F.

AU - Gotesman, Moran

AU - Hayes-Lattin, Brandon

PY - 2024/8/1

Y1 - 2024/8/1

N2 - Adolescents and young adults (ie, individuals aged 15-39 years, known as AYAs) with cancer face unique vulnerabilities yet remain underrepresented in clinical trials, including adult registries of COVID-19 in cancer (AYAs: 8%-12%). We used the Pediatric Oncology COVID-19 Case Report to examine the clinical course of COVID-19 among AYAs with cancer. The Pediatric Oncology COVID-19 Case Report collects deidentified clinical and sociodemographic data regarding individuals aged from birth to 39 years with cancer (37%) and COVID-19 from more than 100 institutions. Between April 1, 2020, and November 28, 2023, 191 older AYAs (individuals 22-39 years of age) and 640 younger AYAs (individuals 15-21 years of age) were captured. Older AYAs were less often hospitalized (P < .001), admitted to the intensive care unit (P = .02), and required respiratory support (P = .057). In multivariable analyses, older AYAs faced 80% lower odds of intensive care unit admission but 2.3-times greater odds of changes to cancer-directed therapy. Unvaccinated patients had 5.4-times higher odds of intensive care unit admission. Among AYAs with cancer, the COVID-19 course varies by age. These findings can inform oncology teams directing COVID-19 management and prevention in AYA patients with cancer.

AB - Adolescents and young adults (ie, individuals aged 15-39 years, known as AYAs) with cancer face unique vulnerabilities yet remain underrepresented in clinical trials, including adult registries of COVID-19 in cancer (AYAs: 8%-12%). We used the Pediatric Oncology COVID-19 Case Report to examine the clinical course of COVID-19 among AYAs with cancer. The Pediatric Oncology COVID-19 Case Report collects deidentified clinical and sociodemographic data regarding individuals aged from birth to 39 years with cancer (37%) and COVID-19 from more than 100 institutions. Between April 1, 2020, and November 28, 2023, 191 older AYAs (individuals 22-39 years of age) and 640 younger AYAs (individuals 15-21 years of age) were captured. Older AYAs were less often hospitalized (P < .001), admitted to the intensive care unit (P = .02), and required respiratory support (P = .057). In multivariable analyses, older AYAs faced 80% lower odds of intensive care unit admission but 2.3-times greater odds of changes to cancer-directed therapy. Unvaccinated patients had 5.4-times higher odds of intensive care unit admission. Among AYAs with cancer, the COVID-19 course varies by age. These findings can inform oncology teams directing COVID-19 management and prevention in AYA patients with cancer.

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UR - http://www.scopus.com/inward/citedby.url?scp=85201029933&partnerID=8YFLogxK

U2 - 10.1093/jnci/djae085

DO - 10.1093/jnci/djae085

M3 - Article

C2 - 38627241

AN - SCOPUS:85201029933

SN - 0027-8874

VL - 116

SP - 1366

EP - 1373

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 8

ER -

Adolescents and young adults with cancer: the clinical course of COVID-19 infections

Abstract

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