Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome

Wei Xie; Philipp W. Raess; Jennifer Dunlap; Cristina Magallanes Hoyos; Hongmei Li; Peng Li; Ronan Swords; Susan B. Olson; Fei Yang; Tauangtham Anekpuritanang; Shimin Hu; Joanna Wiszniewska; Guang Fan; Richard D. Press; Stephen R. Moore

doi:10.1080/10428194.2022.2047672

Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome

Wei Xie, Philipp W. Raess, Jennifer Dunlap, Cristina Magallanes Hoyos, Hongmei Li, Peng Li, Ronan Swords, Susan B. Olson, Fei Yang, Tauangtham Anekpuritanang, Shimin Hu, Joanna Wiszniewska, Guang Fan, Richard D. Press, Stephen R. Moore

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14 Scopus citations

Abstract

Acute myeloid leukemia (AML) with NUP98 rearrangement (AML-NUP98) has been uncommonly reported in adults, and its incidence in our institution is ∼2.5%. There were four men and five women with a median age of 49 years, among which six cases were de novo AML and three were therapy-related. Five cases were AML with minimal differentiation or without maturation, followed by four with monocytic differentiation. NUP98 rearrangement was confirmed in all cases by FISH, and five cases showed cryptic translocations. The median overall survival (OS) was 13 months, shorter than that of AML-NPM1 (p < 0.05), and similar to that in AML-KMT2A patients in our institution. The unfavorable OS was further confirmed by comparing to AML patients in TCGA database. In conclusion, adult AML-NUP98 is associated with cryptic translocations and an unfavorable outcome. Our study suggests that incorporating the NUP98 probe into AML FISH panels are warranted to improve clinical management.

Original language	English (US)
Pages (from-to)	1907-1916
Number of pages	10
Journal	Leukemia and Lymphoma
Volume	63
Issue number	8
DOIs	https://doi.org/10.1080/10428194.2022.2047672
State	Published - 2022

Keywords

Acute myeloid leukemia
NUP98 rearrangement
adult
cryptic translocation

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/10428194.2022.2047672

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Xie, W., Raess, P. W., Dunlap, J., Hoyos, C. M., Li, H., Li, P., Swords, R., Olson, S. B., Yang, F., Anekpuritanang, T., Hu, S., Wiszniewska, J., Fan, G., Press, R. D., & Moore, S. R. (2022). Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome. Leukemia and Lymphoma, 63(8), 1907-1916. https://doi.org/10.1080/10428194.2022.2047672

Xie, W , Raess, PW , Dunlap, J, Hoyos, CM, Li, H, Li, P, Swords, R , Olson, SB, Yang, F, Anekpuritanang, T, Hu, S, Wiszniewska, J , Fan, G , Press, RD & Moore, SR 2022, 'Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome', Leukemia and Lymphoma, vol. 63, no. 8, pp. 1907-1916. https://doi.org/10.1080/10428194.2022.2047672

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title = "Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome",

abstract = "Acute myeloid leukemia (AML) with NUP98 rearrangement (AML-NUP98) has been uncommonly reported in adults, and its incidence in our institution is ∼2.5%. There were four men and five women with a median age of 49 years, among which six cases were de novo AML and three were therapy-related. Five cases were AML with minimal differentiation or without maturation, followed by four with monocytic differentiation. NUP98 rearrangement was confirmed in all cases by FISH, and five cases showed cryptic translocations. The median overall survival (OS) was 13 months, shorter than that of AML-NPM1 (p < 0.05), and similar to that in AML-KMT2A patients in our institution. The unfavorable OS was further confirmed by comparing to AML patients in TCGA database. In conclusion, adult AML-NUP98 is associated with cryptic translocations and an unfavorable outcome. Our study suggests that incorporating the NUP98 probe into AML FISH panels are warranted to improve clinical management.",

keywords = "Acute myeloid leukemia, NUP98 rearrangement, adult, cryptic translocation",

author = "Wei Xie and Raess, {Philipp W.} and Jennifer Dunlap and Hoyos, {Cristina Magallanes} and Hongmei Li and Peng Li and Ronan Swords and Olson, {Susan B.} and Fei Yang and Tauangtham Anekpuritanang and Shimin Hu and Joanna Wiszniewska and Guang Fan and Press, {Richard D.} and Moore, {Stephen R.}",

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doi = "10.1080/10428194.2022.2047672",

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AU - Xie, Wei

AU - Raess, Philipp W.

AU - Dunlap, Jennifer

AU - Hoyos, Cristina Magallanes

AU - Li, Hongmei

AU - Li, Peng

AU - Swords, Ronan

AU - Olson, Susan B.

AU - Yang, Fei

AU - Anekpuritanang, Tauangtham

AU - Hu, Shimin

AU - Wiszniewska, Joanna

AU - Fan, Guang

AU - Press, Richard D.

AU - Moore, Stephen R.

PY - 2022

Y1 - 2022

N2 - Acute myeloid leukemia (AML) with NUP98 rearrangement (AML-NUP98) has been uncommonly reported in adults, and its incidence in our institution is ∼2.5%. There were four men and five women with a median age of 49 years, among which six cases were de novo AML and three were therapy-related. Five cases were AML with minimal differentiation or without maturation, followed by four with monocytic differentiation. NUP98 rearrangement was confirmed in all cases by FISH, and five cases showed cryptic translocations. The median overall survival (OS) was 13 months, shorter than that of AML-NPM1 (p < 0.05), and similar to that in AML-KMT2A patients in our institution. The unfavorable OS was further confirmed by comparing to AML patients in TCGA database. In conclusion, adult AML-NUP98 is associated with cryptic translocations and an unfavorable outcome. Our study suggests that incorporating the NUP98 probe into AML FISH panels are warranted to improve clinical management.

AB - Acute myeloid leukemia (AML) with NUP98 rearrangement (AML-NUP98) has been uncommonly reported in adults, and its incidence in our institution is ∼2.5%. There were four men and five women with a median age of 49 years, among which six cases were de novo AML and three were therapy-related. Five cases were AML with minimal differentiation or without maturation, followed by four with monocytic differentiation. NUP98 rearrangement was confirmed in all cases by FISH, and five cases showed cryptic translocations. The median overall survival (OS) was 13 months, shorter than that of AML-NPM1 (p < 0.05), and similar to that in AML-KMT2A patients in our institution. The unfavorable OS was further confirmed by comparing to AML patients in TCGA database. In conclusion, adult AML-NUP98 is associated with cryptic translocations and an unfavorable outcome. Our study suggests that incorporating the NUP98 probe into AML FISH panels are warranted to improve clinical management.

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KW - cryptic translocation

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Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome

Abstract

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