Adverse events rates and risk factors in adults undergoing cardiac catheterization at pediatric hospitals - Results from the C3PO

Christopher P. Learn, Ralf J. Holzer, Curt J. Daniels, Alejandro J. Torres, Julie A. Vincent, John W. Moore, Laurie B. Armsby, Michael J. Landzberg, Lisa Bergersen

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Objective Determine the frequency and risk factors for adverse events (AE) for adults undergoing cardiac catheterization at pediatric hospitals. Background Adult catheterization AE rates at pediatric hospitals are not well understood. The Congenital Cardiac Catheterization Project on Outcomes (C3PO) collects data on all catheterizations at eight pediatric institutions. Methods Adult (≥18 years) case characteristics and AE were reviewed and compared with those of pediatric (<18 years) cases. Cases were classified into procedure risk categories from 1 to 4 based on highest risk procedure/intervention performed. AE were categorized by level of severity. Using a multivariate model for high severity AE (HSAE), standardized AE rates (SAER) were calculated by dividing the observed rates of HSAE by the expected rates. Results 2,061 cases (15% of total) were performed on adults and 11,422 cases (85%) were performed on children. Adults less frequently underwent high-risk procedure category cases than children (19% vs. 30%). AE occurred in 10% of adult cases and 13% of pediatric cases (P < 0.001). HSAE occurred in 4% of adult and 5% of pediatric cases (P = 0.006). Procedure-type risk category (Category 2, 3, 4 OR = 4.8, 6.0, 12.9) and systemic ventricle end diastolic pressure ≥ 18 mm Hg (OR 3.1) were associated with HSAE, c statistic 0.751. There were no statistically significant differences in SAER among institutions. Conclusions Adults undergoing catheterization at pediatric hospitals encountered AE less frequently than children did. The congenital heart disease adjustment for risk method for adults with congenital heart disease is a new tool for assessing procedural risk in adult patients.

Original languageEnglish (US)
Pages (from-to)997-1005
Number of pages9
JournalCatheterization and Cardiovascular Interventions
Issue number6
StatePublished - May 2013


  • complications
  • congenital
  • heart defects
  • outcome assessment

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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