Adverse ocular reactions possibly associated with isotretinoin

F. T. Fraunfelder, James M. LaBraico, S. Martha Meyer

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


A total of 261 adverse ocular reactions occurred in 237 patients who received isotretinoin, a commonly used drug in the treatment of severe cystic acne. Blepharoconjunctivitis, subjective complaints of dry eyes, blurred vision, contact lens intolerance, and photodermatitis are reversible side effects. More serious ocular adverse reactions include papilledema, pseudotumor cerebri, and white or gray subepithelial corneal opacities; all of these are reversible if the drug is discontinued. Reported cases of decreased dark adaptation are under investigation. Isotretinoin is contraindicated in pregnancy because of the many reported congenital abnormalities after maternal use (including microphthalmos, orbital hypertelorism, and optic nerve hypoplasia).

Original languageEnglish (US)
Pages (from-to)534-537
Number of pages4
JournalAmerican journal of ophthalmology
Issue number4
StatePublished - Oct 1985
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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