TY - JOUR
T1 - Adverse ocular reactions possibly associated with isotretinoin
AU - Fraunfelder, F. T.
AU - LaBraico, James M.
AU - Meyer, S. Martha
N1 - Funding Information:
From the Department of Ophthalmology and the National Registry of Drug-Induced Ocular Side Effects, Portland, Oregon (Dr. Fraunfelder and Ms. Meyer), and Hoffmann-La Roche, Inc., Nutley, New Jersey (Dr. LaBraico). This study was supported in part by Contract No. 223-82-3012 from the Food and Drug Administration, Research to Prevent Blindness, Inc., and the Helene Halliday Research Fund.
PY - 1985/10
Y1 - 1985/10
N2 - A total of 261 adverse ocular reactions occurred in 237 patients who received isotretinoin, a commonly used drug in the treatment of severe cystic acne. Blepharoconjunctivitis, subjective complaints of dry eyes, blurred vision, contact lens intolerance, and photodermatitis are reversible side effects. More serious ocular adverse reactions include papilledema, pseudotumor cerebri, and white or gray subepithelial corneal opacities; all of these are reversible if the drug is discontinued. Reported cases of decreased dark adaptation are under investigation. Isotretinoin is contraindicated in pregnancy because of the many reported congenital abnormalities after maternal use (including microphthalmos, orbital hypertelorism, and optic nerve hypoplasia).
AB - A total of 261 adverse ocular reactions occurred in 237 patients who received isotretinoin, a commonly used drug in the treatment of severe cystic acne. Blepharoconjunctivitis, subjective complaints of dry eyes, blurred vision, contact lens intolerance, and photodermatitis are reversible side effects. More serious ocular adverse reactions include papilledema, pseudotumor cerebri, and white or gray subepithelial corneal opacities; all of these are reversible if the drug is discontinued. Reported cases of decreased dark adaptation are under investigation. Isotretinoin is contraindicated in pregnancy because of the many reported congenital abnormalities after maternal use (including microphthalmos, orbital hypertelorism, and optic nerve hypoplasia).
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U2 - 10.1016/0002-9394(85)90676-2
DO - 10.1016/0002-9394(85)90676-2
M3 - Article
C2 - 2931989
AN - SCOPUS:0022388642
SN - 0002-9394
VL - 100
SP - 534
EP - 537
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 4
ER -