Alcohol psychopharmacogenetics

John C. Crabbe

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Of all drugs of abuse studied to determine genetic contributions to susceptibility to their effects, alcohol has been by far the most frequent focus. Both animal model and human genetic studies will be mentioned here. A historically rich literature with genetic animal models has explored the general contribution of genetics to alcohol responsiveness, and has been helpful in elucidating the drug’s mechanism of action on the nervous system. Some studies using genetic animal models have attempted to identify specific genes that increase or decrease responsiveness for a number of alcohol’s effects. Most human studies have been of alcoholics and their relatives, and have compared relative risks for alcohol dependence disorders in twins, adoptees, or other relatives. More recently, human studies have also addressed the goal of identifying individual genes that might contribute to alcoholism risk, or to individual differences in endophenotypes, which also are associated with alcoholism risk.

Original languageEnglish (US)
Title of host publicationNeurobehavioral Genetics
Subtitle of host publicationMethods and Applications, Second Edition
PublisherCRC Press
Number of pages12
ISBN (Electronic)9781420003567
ISBN (Print)084931903X, 9780849319037
StatePublished - Jan 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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