Alpha2b-adrenergic receptor regulates neutrophil recruitment in MSU-induced peritoneal inflammation

Lihua Duan, Jie Chen, Michael Razavi, Yingying Wei, Ying Tao, Xiaoquan Rao, Jixin Zhong

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Gout is one of the most common metabolic disorders in human. Previous studies have shown that the disease activity is closely associated with sympathetic nervous system (SNS). α2B-adrenergic receptor (α2BAR), a subtype of α2 adrenergic receptor, plays a critical role in many diseases. However, the role of α2BAR in the pathogenesis of gout remains unclear. Here, we assessed the role of α2BAR in the monosodium urate (MSU) crystals-induced peritonitis that mimics human gout by using the α2BAR-overexpressing mice (α2BAR-Tg). We found that the number of recruited neutrophils was significantly increased in the α2BAR-Tg mice after MSU treatment, when compared with wild type mice. In contrast, the number of macrophages was not changed. Importantly, there is no difference in the IL-1β levels and caspase-1 activity between wild type and α2BAR-Tg mice in the gout animal model. Notably, the enhanced neutrophil migration in α2BAR-Tg mice was dependent on the α2BAR overexpression in neutrophils, but not resulted from other tissues or cells with α2BAR overexpression. In conclusion, our data provide a direct evidence that α2BAR plays a critical role in neutrophil migration and MSU-induced inflammation.

Original languageEnglish (US)
Article number501
JournalFrontiers in immunology
Issue numberMAR
StatePublished - 2019


  • Adrenergic receptor
  • Gout
  • Inflammation
  • Monosodium urate
  • Neutrophil

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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