Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Merel C. Postema; Daan van Rooij; Evdokia Anagnostou; Celso Arango; Guillaume Auzias; Marlene Behrmann; Geraldo Busatto Filho; Sara Calderoni; Rosa Calvo; Eileen Daly; Christine Deruelle; Adriana Di Martino; Ilan Dinstein; Fabio Luis S. Duran; Sarah Durston; Christine Ecker; Stefan Ehrlich; Damien Fair; Jennifer Fedor; Xin Feng; Jackie Fitzgerald; Dorothea L. Floris; Christine M. Freitag; Louise Gallagher; David C. Glahn; Ilaria Gori; Shlomi Haar; Liesbeth Hoekstra; Neda Jahanshad; Maria Jalbrzikowski; Joost Janssen; Joseph A. King; Xiang Zhen Kong; Luisa Lazaro; Jason P. Lerch; Beatriz Luna; Mauricio M. Martinho; Jane McGrath; Sarah E. Medland; Filippo Muratori; Clodagh M. Murphy; Declan G.M. Murphy; Kirsten O’Hearn; Bob Oranje; Mara Parellada; Olga Puig; Alessandra Retico; Pedro Rosa; Katya Rubia; Devon Shook; Margot J. Taylor; Michela Tosetti; Gregory L. Wallace; Fengfeng Zhou; Paul M. Thompson; Simon E. Fisher; Jan K. Buitelaar; Clyde Francks

doi:10.1038/s41467-019-13005-8

Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Merel C. Postema, Daan van Rooij, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Geraldo Busatto Filho, Sara Calderoni, Rosa Calvo, Eileen Daly, Christine Deruelle, Adriana Di Martino, Ilan Dinstein, Fabio Luis S. Duran, Sarah Durston, Christine Ecker, Stefan Ehrlich, Damien Fair, Jennifer Fedor, Xin FengJackie Fitzgerald, Dorothea L. Floris, Christine M. Freitag, Louise Gallagher, David C. Glahn, Ilaria Gori, Shlomi Haar, Liesbeth Hoekstra, Neda Jahanshad, Maria Jalbrzikowski, Joost Janssen, Joseph A. King, Xiang Zhen Kong, Luisa Lazaro, Jason P. Lerch, Beatriz Luna, Mauricio M. Martinho, Jane McGrath, Sarah E. Medland, Filippo Muratori, Clodagh M. Murphy, Declan G.M. Murphy, Kirsten O’Hearn, Bob Oranje, Mara Parellada, Olga Puig, Alessandra Retico, Pedro Rosa, Katya Rubia, Devon Shook, Margot J. Taylor, Michela Tosetti, Gregory L. Wallace, Fengfeng Zhou, Paul M. Thompson, Simon E. Fisher, Jan K. Buitelaar, Clyde Francks

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen’s d = −0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.

Original language	English (US)
Article number	4958
Journal	Nature communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-13005-8
State	Published - Dec 1 2019

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Postema, M. C., van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Filho, G. B., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Di Martino, A., Dinstein, I., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J., ... Francks, C. (2019). Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets. Nature communications, 10(1), Article 4958. https://doi.org/10.1038/s41467-019-13005-8

Postema, MC, van Rooij, D, Anagnostou, E, Arango, C, Auzias, G, Behrmann, M, Filho, GB, Calderoni, S, Calvo, R, Daly, E, Deruelle, C, Di Martino, A, Dinstein, I, Duran, FLS, Durston, S, Ecker, C, Ehrlich, S, Fair, D, Fedor, J, Feng, X, Fitzgerald, J, Floris, DL, Freitag, CM, Gallagher, L, Glahn, DC, Gori, I, Haar, S, Hoekstra, L, Jahanshad, N, Jalbrzikowski, M, Janssen, J, King, JA, Kong, XZ, Lazaro, L, Lerch, JP, Luna, B, Martinho, MM, McGrath, J, Medland, SE, Muratori, F, Murphy, CM, Murphy, DGM, O’Hearn, K, Oranje, B, Parellada, M, Puig, O, Retico, A, Rosa, P, Rubia, K, Shook, D, Taylor, MJ, Tosetti, M, Wallace, GL, Zhou, F, Thompson, PM, Fisher, SE, Buitelaar, JK & Francks, C 2019, 'Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets', Nature communications, vol. 10, no. 1, 4958. https://doi.org/10.1038/s41467-019-13005-8

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abstract = "Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen{\textquoteright}s d = −0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.",

author = "Postema, {Merel C.} and {van Rooij}, Daan and Evdokia Anagnostou and Celso Arango and Guillaume Auzias and Marlene Behrmann and Filho, {Geraldo Busatto} and Sara Calderoni and Rosa Calvo and Eileen Daly and Christine Deruelle and {Di Martino}, Adriana and Ilan Dinstein and Duran, {Fabio Luis S.} and Sarah Durston and Christine Ecker and Stefan Ehrlich and Damien Fair and Jennifer Fedor and Xin Feng and Jackie Fitzgerald and Floris, {Dorothea L.} and Freitag, {Christine M.} and Louise Gallagher and Glahn, {David C.} and Ilaria Gori and Shlomi Haar and Liesbeth Hoekstra and Neda Jahanshad and Maria Jalbrzikowski and Joost Janssen and King, {Joseph A.} and Kong, {Xiang Zhen} and Luisa Lazaro and Lerch, {Jason P.} and Beatriz Luna and Martinho, {Mauricio M.} and Jane McGrath and Medland, {Sarah E.} and Filippo Muratori and Murphy, {Clodagh M.} and Murphy, {Declan G.M.} and Kirsten O{\textquoteright}Hearn and Bob Oranje and Mara Parellada and Olga Puig and Alessandra Retico and Pedro Rosa and Katya Rubia and Devon Shook and Taylor, {Margot J.} and Michela Tosetti and Wallace, {Gregory L.} and Fengfeng Zhou and Thompson, {Paul M.} and Fisher, {Simon E.} and Buitelaar, {Jan K.} and Clyde Francks",

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AU - Auzias, Guillaume

AU - Behrmann, Marlene

AU - Filho, Geraldo Busatto

AU - Calderoni, Sara

AU - Calvo, Rosa

AU - Daly, Eileen

AU - Deruelle, Christine

AU - Di Martino, Adriana

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AU - Jahanshad, Neda

AU - Jalbrzikowski, Maria

AU - Janssen, Joost

AU - King, Joseph A.

AU - Kong, Xiang Zhen

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AU - Lerch, Jason P.

AU - Luna, Beatriz

AU - Martinho, Mauricio M.

AU - McGrath, Jane

AU - Medland, Sarah E.

AU - Muratori, Filippo

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AU - Tosetti, Michela

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AU - Zhou, Fengfeng

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AU - Buitelaar, Jan K.

AU - Francks, Clyde

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Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

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