TY - JOUR
T1 - An fMRI-compatible force measurement system for the evaluation of the neural correlates of step initiation
AU - De Lima-Pardini, Andrea Cristina
AU - De Azevedo Neto, Raymundo Mac Hado
AU - Coelho, Daniel Boari
AU - Boffino, Catarina Costa
AU - Shergill, Sukhwinder S.
AU - De Oliveira Souza, Carolina
AU - Brant, Rachael
AU - Barbosa, Egberto Reis
AU - Cardoso, Ellison Fernando
AU - Teixeira, Luis Augusto
AU - Cohen, Rajal G.
AU - Horak, Fay Bahling
AU - Amaro, Edson
N1 - Funding Information:
This work was supported by the Saõ Paulo Research Foundation (FAPESP), Saõ Paulo, Saõ Paulo (2013/15256-0: grant to ACLP) and by the National institute of General Medical Sciences at the National Institutes of Health (grant number 5U54GM104944: pilot grant to RGC).
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/2/23
Y1 - 2017/2/23
N2 - Knowledge of brain correlates of postural control is limited by the technical difficulties in performing controlled experiments with currently available neuroimaging methods. Here we present a system that allows the measurement of anticipatory postural adjustment of human legs to be synchronized with the acquisition of functional magnetic resonance imaging data. The device is composed of Magnetic Resonance Imaging (MRI) compatible force sensors able to measure the level of force applied by both feet. We tested the device in a group of healthy young subjects and a group of elderly subjects with Parkinson's disease using an event-related functional MRI (fMRI) experiment design. In both groups the postural behavior inside the magnetic resonance was correlated to the behavior during gait initiation outside the scanner. The system did not produce noticeable imaging artifacts in the data. Healthy young people showed brain activation patterns coherent with movement planning. Parkinson's disease patients demonstrated an altered pattern of activation within the motor circuitry. We concluded that this force measurement system is able to index both normal and abnormal preparation for gait initiation within an fMRI experiment.
AB - Knowledge of brain correlates of postural control is limited by the technical difficulties in performing controlled experiments with currently available neuroimaging methods. Here we present a system that allows the measurement of anticipatory postural adjustment of human legs to be synchronized with the acquisition of functional magnetic resonance imaging data. The device is composed of Magnetic Resonance Imaging (MRI) compatible force sensors able to measure the level of force applied by both feet. We tested the device in a group of healthy young subjects and a group of elderly subjects with Parkinson's disease using an event-related functional MRI (fMRI) experiment design. In both groups the postural behavior inside the magnetic resonance was correlated to the behavior during gait initiation outside the scanner. The system did not produce noticeable imaging artifacts in the data. Healthy young people showed brain activation patterns coherent with movement planning. Parkinson's disease patients demonstrated an altered pattern of activation within the motor circuitry. We concluded that this force measurement system is able to index both normal and abnormal preparation for gait initiation within an fMRI experiment.
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U2 - 10.1038/srep43088
DO - 10.1038/srep43088
M3 - Article
C2 - 28230070
AN - SCOPUS:85013814855
SN - 2045-2322
VL - 7
JO - Scientific Reports
JF - Scientific Reports
M1 - 43088
ER -