An integrated MRI and MRS approach to evaluation of multiple sclerosis with cognitive impairment

Zhengrong Liang, Hong Li, Hongbing Lu, Wei Huang, Alina Tudorica, Lauren Krupp

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Magnetic resonance imaging and spectroscopy (MRI/MRS) plays a unique role in multiple sclerosis (MS) evaluation, because of its ability to provide both high image contrast and significant chemical change among brain tissues. The image contrast renders the possibility of quantifying the tissue volumetric and texture variations, e.g., cerebral atrophy and progressing speed, reflecting the ongoing destructive pathologic processes. Any chemical change reflects an early sign of pathological alteration, e.g., decreased N-acetyl aspartate (NAA) in lesions and normal appearing white matter, related to axonal damage or dysfunction. Both MRI and MRS encounter partial volume (PV) effect, which compromises the quantitative capability, especially for MRS. This work aims to develop a statistical framework to segment the tissue mixtures inside each image element, eliminating theoretically the PV effect, and apply the framework to the evaluation of MS with cognitive impairment. The quantitative measures from MRI/MRS neuroimaging are strongly correlated with the qualitative neuropsychological scores of Brief Repeatable Battery (BRB) test on cognitive impairment, demonstrating the usefulness of the PV image segmentation framework in this clinically significant problem.

Original languageEnglish (US)
Title of host publicationMedical Biometrics - First International Conference, ICMB 2008, Proceedings
Number of pages8
StatePublished - 2008
Externally publishedYes
Event1st International Conference on Medical Biometrics, ICMB 2008 - Hong Kong, Hong Kong
Duration: Jan 4 2008Jan 5 2008

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4901 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other1st International Conference on Medical Biometrics, ICMB 2008
Country/TerritoryHong Kong
CityHong Kong

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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