An Unusual Presentation of Inflammatory Shoulder Arthritis Associated with Nivolumab: A Case Report

Sarah E. Lindsay; Lindsey Wurster; Kirsten Woolf; Kenneth R. Gundle

doi:10.2106/JBJS.CC.21.00301

An Unusual Presentation of Inflammatory Shoulder Arthritis Associated with Nivolumab: A Case Report

Sarah E. Lindsay, Lindsey Wurster, Kirsten Woolf, Kenneth R. Gundle

Orthopaedics and Rehabilitation

Research output: Contribution to journal › Article › peer-review

Abstract

Case:A 68-year-old woman with a history of stage IIIC (T3bN1bM0) melanoma with metastases to her right axilla status after 10 cycles of nivolumab presented with right shoulder pain. Radiographs showed a progressive erosive glenohumeral joint lesion. The workup was negative for metastasis and infection. Her clinical and radiographic findings were consistent with erosive arthritis. The patient underwent shoulder hemiarthroplasty and experienced substantial improvements.Conclusion:This is an unusual case of inflammatory arthritis associated with nivolumab, an antiprogrammed cell death protein 1, and is an important reminder of the musculoskeletal toxicities associated with immunotherapies.

Original language	English (US)
Article number	e21.00301
Journal	JBJS case connector
Volume	11
Issue number	4
DOIs	https://doi.org/10.2106/JBJS.CC.21.00301
State	Published - Oct 20 2021

Keywords

erosive arthritis
immunotherapy
inflammatory arthritis
melanoma
nivolumab
shoulder arthroplasty

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

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10.2106/JBJS.CC.21.00301

Cite this

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abstract = "Case:A 68-year-old woman with a history of stage IIIC (T3bN1bM0) melanoma with metastases to her right axilla status after 10 cycles of nivolumab presented with right shoulder pain. Radiographs showed a progressive erosive glenohumeral joint lesion. The workup was negative for metastasis and infection. Her clinical and radiographic findings were consistent with erosive arthritis. The patient underwent shoulder hemiarthroplasty and experienced substantial improvements.Conclusion:This is an unusual case of inflammatory arthritis associated with nivolumab, an antiprogrammed cell death protein 1, and is an important reminder of the musculoskeletal toxicities associated with immunotherapies.",

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AU - Gundle, Kenneth R.

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AB - Case:A 68-year-old woman with a history of stage IIIC (T3bN1bM0) melanoma with metastases to her right axilla status after 10 cycles of nivolumab presented with right shoulder pain. Radiographs showed a progressive erosive glenohumeral joint lesion. The workup was negative for metastasis and infection. Her clinical and radiographic findings were consistent with erosive arthritis. The patient underwent shoulder hemiarthroplasty and experienced substantial improvements.Conclusion:This is an unusual case of inflammatory arthritis associated with nivolumab, an antiprogrammed cell death protein 1, and is an important reminder of the musculoskeletal toxicities associated with immunotherapies.

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An Unusual Presentation of Inflammatory Shoulder Arthritis Associated with Nivolumab: A Case Report

Abstract

Keywords

ASJC Scopus subject areas

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