Abstract
Neuroprotectants are drugs designed to treat stroke by preserving ischemic neurons in the penumbra. Despite numerous studies over the past ten years, no such drug has yet shown clinical efficacy. The article reviews those trials completed since 1999, including assessments of drugs that modify receptors or ion flow, block leukocyte adhesion receptors or stabilize membranes. In addition, ongoing trials and early trials using novel mechanisms of action, such as hypothermia and antioxidants, are discussed.
Original language | English (US) |
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Pages (from-to) | 1732-1736 |
Number of pages | 5 |
Journal | Current Opinion in Investigational Drugs |
Volume | 2 |
Issue number | 12 |
State | Published - 2001 |
Keywords
- Acute stroke treatment
- Clinical trials
- Neuprotection
- Penumbra
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery