An update of neuroprotectants in clinical development for acute stroke

Helmi Lutsep, Wayne Clark

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Neuroprotectants are drugs designed to treat stroke by preserving ischemic neurons in the penumbra. Despite numerous studies over the past ten years, no such drug has yet shown clinical efficacy. The article reviews those trials completed since 1999, including assessments of drugs that modify receptors or ion flow, block leukocyte adhesion receptors or stabilize membranes. In addition, ongoing trials and early trials using novel mechanisms of action, such as hypothermia and antioxidants, are discussed.

Original languageEnglish (US)
Pages (from-to)1732-1736
Number of pages5
JournalCurrent Opinion in Investigational Drugs
Issue number12
StatePublished - 2001


  • Acute stroke treatment
  • Clinical trials
  • Neuprotection
  • Penumbra

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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