Anal cancer: Current standards in care and recent changes in practice

Ravi Shridhar, David Shibata, Emily Chan, Charles R. Thomas

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations


Answer questions and earn CME/CNE The management of squamous cell carcinomas of the anal canal has evolved from surgery as first-line treatment to curative chemoradiation, with surgery reserved for salvage. Significant progress has been made in understanding how to most effectively deliver chemotherapy and reduce toxicity through advancements in radiation delivery. The purpose of this article is to review the multimodality approach to the diagnosis and management of anal cancer based on a review of the published data and in light of available guidelines. CA Cancer J Clin 2015;65: 139-162.

Original languageEnglish (US)
Pages (from-to)139-162
Number of pages24
JournalCA Cancer Journal for Clinicians
Issue number2
StatePublished - Mar 1 2015
Externally publishedYes


  • abdominoperineal resection
  • anal cancer
  • brachytherapy
  • chemoradiation
  • chemotherapy
  • intensity modulated radiation therapy
  • quality of life
  • salvage therapy
  • sentinel lymph node biopsy
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Hematology
  • Oncology


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