Anal intraepithelial neoplasia: Diagnosis, screening, and treatment

Ragavan V. Siddharthana, Christian Lanciault, Vassiliki Liana Tsikitis

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Anal intraepithelial neoplasia (AIN) is a premalignant lesion for anal cancer. It is more commonly found in high-risk patients (e.g., human papilloma virus (HPV)/human immunodeficiency virus infections, post-organ transplantation patients, and men who have sex with men) and development is driven by HPV infection. The incidence of AIN is difficult to estimate, but is heavily skewed by preexisting conditions, particularly in high-risk populations. The diagnosis is made from cytology or biopsy during routine examinations, and can be performed at a primary care provider’s office. A pathologist can then review and classify cells, based on nucleus-to-cytoplasm ratios. The classification of low or high grade can better predict progression from AIN to anal cancer. There is little debate that AIN can develop into anal cancer, and the main rationale for treatment is to delay the progression. Significant controversy remains regarding screening, surveillance, and treatment for AIN. Management options are separated into surveillance (watchful waiting) and interventional strategies. Emerging data suggest that close patient follow up with a combination of ablative and topical treatments may offer the greatest benefit. HPV vaccination offers a unique treatment prior to HPV infection and the subsequent development of AIN, but its use after the development of AIN is limited. Ablative treatment includes excision, fulguration, and laser therapy.

Original languageEnglish (US)
Pages (from-to)257-263
Number of pages7
JournalAnnals of Gastroenterology
Issue number3
StatePublished - May 3 2019


  • Anal intraepithelial neoplasia
  • Hpv-related squamous epithelial dysplasia
  • Human papilloma virus (HPV)

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Anal intraepithelial neoplasia: Diagnosis, screening, and treatment'. Together they form a unique fingerprint.

Cite this