Analysis of 4D myocardial wall motion during early stages of chick heart development

Madeline Midgett, Sandra Rugonyi

Research output: Contribution to journalArticlepeer-review


4D myocardial wall motion analysis (3D structure over time) during early embryonic stages of chick heart development provides a comprehensive view to characterize the biomechanical environment of cardiac growth. Myocardial wall strains, velocity, and area shortening over the cardiac cycle are common wall motion assessments and can be accurately measured from 4D datasets. Here, we describe how to employ a variety of image modalities (optical, ultrasound, and optical coherence tomography imaging) and analysis techniques to extract quantitative measures of myocardial wall motion.

Original languageEnglish (US)
Pages (from-to)191-212
Number of pages22
JournalMethods in Molecular Biology
StatePublished - 2015


  • 4D reconstruction
  • 4D synchronization
  • Cardiac segmentation
  • Chick heart development
  • Myocardial wall motion
  • Optical coherence tomography (OCT) imaging
  • Optical imaging
  • Ultrasound imaging

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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