Abstract
The factors and processes involved in regression of the primate corpus luteum (CL) are complex and not fully understood. Systemic identification of those genes that are differentially expressed utilizing macaque model systems of luteal regression could help clarify some of the important molecular events involved in loss of primate luteal structure and function during luteolysis. In addition, examining gene pathways involved in luteal regression may help elucidate novel approaches for overcoming infertility or designing ovary-based contraceptives. This review provides an overview of the current published microarray experiments evaluating the transcriptome of the macaque CL, and compares and contrasts the data from spontaneous, GnRH antagonist and prostaglandin F2α-induced luteal regression. In addition, further uses of these databases are discussed, as well as limitations of both array technology and the rhesus macaque genome array.
Original language | English (US) |
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Article number | gaq080 |
Pages (from-to) | 143-151 |
Number of pages | 9 |
Journal | Molecular Human Reproduction |
Volume | 17 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2011 |
Keywords
- Corpus luteum
- Gonadotrophins
- Microarray
- Primate
- Prostaglandins
ASJC Scopus subject areas
- Reproductive Medicine
- Embryology
- Molecular Biology
- Genetics
- Obstetrics and Gynecology
- Developmental Biology
- Cell Biology