Angiographic and structural imaging using high axial resolution fiber-based visible-light OCT

Shaohua Pi, Acner Camino, Miao Zhang, William Cepurna, Gangjun Liu, David Huang, John Morrison, Yali Jia

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Optical coherence tomography using visible-light sources can increase the axial resolution without the need for broader spectral bandwidth. Here, a high-resolution, fiberbased, visible-light optical coherence tomography system is built and used to image normal retina in rats and blood vessels in chicken embryo. In the rat retina, accurate segmentation of retinal layer boundaries and quantification of layer thicknesses are accomplished. Furthermore, three distinct capillary plexuses in the retina and the choriocapillaris are identified and the characteristic pattern of the nerve fiber layer thickness in rats is revealed. In the chicken embryo model, the microvascular network and a venous bifurcation are examined and the ability to identify and segment large vessel walls is demonstrated.

Original languageEnglish (US)
Article number#304064
Pages (from-to)4595-4608
Number of pages14
JournalBiomedical Optics Express
Issue number10
StatePublished - Oct 1 2017


  • (100.2980) image enhancement
  • (110.4500) optical coherence tomography
  • (170.2655) functional monitoring and imaging
  • (170.4470) ophthalmology

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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