TY - JOUR
T1 - Angiographic and structural imaging using high axial resolution fiber-based visible-light OCT
AU - Pi, Shaohua
AU - Camino, Acner
AU - Zhang, Miao
AU - Cepurna, William
AU - Liu, Gangjun
AU - Huang, David
AU - Morrison, John
AU - Jia, Yali
N1 - Funding Information:
This work was supported by grant R01 EY027833, DP3 DK104397, R01 EY024544, R01 EY023285, R01 EY010145, P30 EY010572 from the National Institutes of Health (Bethesda, MD), and an unrestricted departmental funding grant and William & Mary Greve Special Scholar Award from Research to Prevent Blindness (New York, NY).
Publisher Copyright:
© 2017 Optical Society of America.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Optical coherence tomography using visible-light sources can increase the axial resolution without the need for broader spectral bandwidth. Here, a high-resolution, fiberbased, visible-light optical coherence tomography system is built and used to image normal retina in rats and blood vessels in chicken embryo. In the rat retina, accurate segmentation of retinal layer boundaries and quantification of layer thicknesses are accomplished. Furthermore, three distinct capillary plexuses in the retina and the choriocapillaris are identified and the characteristic pattern of the nerve fiber layer thickness in rats is revealed. In the chicken embryo model, the microvascular network and a venous bifurcation are examined and the ability to identify and segment large vessel walls is demonstrated.
AB - Optical coherence tomography using visible-light sources can increase the axial resolution without the need for broader spectral bandwidth. Here, a high-resolution, fiberbased, visible-light optical coherence tomography system is built and used to image normal retina in rats and blood vessels in chicken embryo. In the rat retina, accurate segmentation of retinal layer boundaries and quantification of layer thicknesses are accomplished. Furthermore, three distinct capillary plexuses in the retina and the choriocapillaris are identified and the characteristic pattern of the nerve fiber layer thickness in rats is revealed. In the chicken embryo model, the microvascular network and a venous bifurcation are examined and the ability to identify and segment large vessel walls is demonstrated.
KW - (100.2980) image enhancement
KW - (110.4500) optical coherence tomography
KW - (170.2655) functional monitoring and imaging
KW - (170.4470) ophthalmology
UR - http://www.scopus.com/inward/record.url?scp=85031008276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031008276&partnerID=8YFLogxK
U2 - 10.1364/BOE.8.004595
DO - 10.1364/BOE.8.004595
M3 - Article
AN - SCOPUS:85031008276
SN - 2156-7085
VL - 8
SP - 4595
EP - 4608
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 10
M1 - #304064
ER -