Abstract
This review highlights new information gained from studies using recently developed animal models that harbor specific alterations in corticotropin-releasing hormone (CRH) pathways. We discuss features of a transgenic mouse model of chronic CRH overexpression and two mouse models that lack either CRH receptor type 1 (CRH-R1) or type 2 (CRH-R2). Together these models provide new insights into the role of CRH pathways in promoting stability through adaptive changes, a process known as allostasis.
Original language | English (US) |
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Pages (from-to) | 733-741 |
Number of pages | 9 |
Journal | Peptides |
Volume | 22 |
Issue number | 5 |
DOIs | |
State | Published - 2001 |
Keywords
- Allostasis
- Corticotropin-releasing hormone
- Knock-out mice
- Stress
- Transgenic
- Urocortin
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Endocrinology
- Cellular and Molecular Neuroscience