Antagonism of nitrous oxide antinociception in mice by antisense oligodeoxynucleotide directed against neuronal nitric oxide synthase enzyme

Shuang Li; Andrew J. Bieber; Raymond M. Quock

doi:10.1016/j.bbr.2003.10.019

Antagonism of nitrous oxide antinociception in mice by antisense oligodeoxynucleotide directed against neuronal nitric oxide synthase enzyme

Shuang Li, Andrew J. Bieber, Raymond M. Quock

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Nitric oxide (NO) has been implicated in the antinociceptive effect of nitrous oxide (N₂O) in mice. This study was conducted to determine the sensitivity of N₂O-induced antinociception to antagonism by an antisense oligodeoxynucleotide (AS-ODN) against neuronal nitric oxide synthase (nNOS). The AS-ODN significantly antagonized the antinociceptive effect of N₂O in the abdominal constriction test, but a mismatch ODN was without effect. This result implicates the specific involvement of nNOS in N₂O-induced antinociception.

Original language	English (US)
Pages (from-to)	361-363
Number of pages	3
Journal	Behavioural Brain Research
Volume	152
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2003.10.019
State	Published - Jul 9 2004
Externally published	Yes

Keywords

Antinociceptive effect
Antisense
Mice
Nitric oxide
Nitrous oxide

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2003.10.019

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title = "Antagonism of nitrous oxide antinociception in mice by antisense oligodeoxynucleotide directed against neuronal nitric oxide synthase enzyme",

abstract = "Nitric oxide (NO) has been implicated in the antinociceptive effect of nitrous oxide (N2O) in mice. This study was conducted to determine the sensitivity of N2O-induced antinociception to antagonism by an antisense oligodeoxynucleotide (AS-ODN) against neuronal nitric oxide synthase (nNOS). The AS-ODN significantly antagonized the antinociceptive effect of N2O in the abdominal constriction test, but a mismatch ODN was without effect. This result implicates the specific involvement of nNOS in N2O-induced antinociception.",

keywords = "Antinociceptive effect, Antisense, Mice, Nitric oxide, Nitrous oxide",

author = "Shuang Li and Bieber, {Andrew J.} and Quock, {Raymond M.}",

note = "Funding Information: This work was support by NIH Grant DA-10343.",

year = "2004",

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doi = "10.1016/j.bbr.2003.10.019",

language = "English (US)",

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T1 - Antagonism of nitrous oxide antinociception in mice by antisense oligodeoxynucleotide directed against neuronal nitric oxide synthase enzyme

AU - Li, Shuang

AU - Bieber, Andrew J.

AU - Quock, Raymond M.

N1 - Funding Information: This work was support by NIH Grant DA-10343.

PY - 2004/7/9

Y1 - 2004/7/9

N2 - Nitric oxide (NO) has been implicated in the antinociceptive effect of nitrous oxide (N2O) in mice. This study was conducted to determine the sensitivity of N2O-induced antinociception to antagonism by an antisense oligodeoxynucleotide (AS-ODN) against neuronal nitric oxide synthase (nNOS). The AS-ODN significantly antagonized the antinociceptive effect of N2O in the abdominal constriction test, but a mismatch ODN was without effect. This result implicates the specific involvement of nNOS in N2O-induced antinociception.

AB - Nitric oxide (NO) has been implicated in the antinociceptive effect of nitrous oxide (N2O) in mice. This study was conducted to determine the sensitivity of N2O-induced antinociception to antagonism by an antisense oligodeoxynucleotide (AS-ODN) against neuronal nitric oxide synthase (nNOS). The AS-ODN significantly antagonized the antinociceptive effect of N2O in the abdominal constriction test, but a mismatch ODN was without effect. This result implicates the specific involvement of nNOS in N2O-induced antinociception.

KW - Antinociceptive effect

KW - Antisense

KW - Mice

KW - Nitric oxide

KW - Nitrous oxide

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Antagonism of nitrous oxide antinociception in mice by antisense oligodeoxynucleotide directed against neuronal nitric oxide synthase enzyme

Abstract

Keywords

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