Antenatal cerebral necrosis in monochorionic twins

Marjorie R. Grafe

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Antenatal cerebral white matter necrosis occurs relatively frequently in monochorionic twins, particularly when one twin has died in utero or in the twin-twin transfusion syndrome. A case of antenatal cerebral necrosis in both of liveborn monochorionic twins is presented. It is proposed that placental artery-to-artery or vein-to-vein anastomoses may predispose twin fetuses to hemodynamic instability. Fluctuations in blood pressure or blood volume may then result in cerebral necrosis, without requiring the death of one twin or transfer of a blood-borne factor from one twin to the other..

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalFetal and Pediatric Pathology
Issue number1
StatePublished - 1993
Externally publishedYes


  • Cerebral necrosis
  • Monochorionic twins
  • Transfusion syndrome
  • White matter necrosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


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