Anterior Pituitary Failure

Research output: Chapter in Book/Report/Conference proceedingChapter


Anterior pituitary failure results from a variety of different etiologies; sellar/suprasellar masses and treatment(s), infiltrative and infectious diseases, genetic mutations, and traumatic brain injury are the most frequent causes of hypopituitarism. If not recognized and appropriately treated, hypopituitarism leads to increased mortality. The clinical presentation of hypopituitarism is determined by underlying etiology, age of onset, and the number and type of pituitary hormones affected. A diagnosis of pituitary failure relies on measurement(s) of anterior pituitary hormones and related target hormones. Dynamic testing is required when a diagnosis cannot be made by baseline hormonal evaluation. Depending on the clinical picture and desired outcome, treatment of hypopituitarism typically involves the replacement of target hormones (cortisol, thyroid hormone, gonadal hormones) or pituitary hormones (growth hormone; occasionally follicle-stimulating hormone and luteinizing hormone), and, in rare cases, hypothalamic hormones.

Original languageEnglish (US)
Title of host publicationThe Pituitary
Number of pages34
ISBN (Electronic)9780323998994
ISBN (Print)9780323985338
StatePublished - Jan 1 2022


  • Adrenal insufficiency
  • Central hypothyroidism
  • Diagnostic testing
  • Growth hormone deficiency
  • Hormone replacement
  • Hypogonadism
  • Hypopituitarism
  • Pituitary failure
  • Pituitary function testing

ASJC Scopus subject areas

  • General Medicine


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