Abstract
It is becoming increasingly apparent that nuclear antigens can be expressed on the surfaces of certain cells. The authors provide evidence that anti-DNA antibodies are reactive with DNA on the surface of monocytes and B lymphocytes. The DNA isolated from monocytes sedimented in a 17.8S position, corresponding to a molecular weight of 4.6 x 106; it was mainly double-stranded with many short single stranded regions. In one patient with active systemic lupus erythematosus experiments indicated that anti-DNA antibodies had interacted in vivo with the cell surface DNA on monocytes. The functional significance, if any, of these findings remains to be determined.
Original language | English (US) |
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Pages (from-to) | 679-685 |
Number of pages | 7 |
Journal | Journal of Rheumatology |
Volume | 13 |
Issue number | 4 |
State | Published - 1986 |
Externally published | Yes |
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology