TY - JOUR
T1 - Antifibrinolytics Reduce Blood Loss in Adult Spinal Deformity Surgery
T2 - A Prospective, Randomized Controlled Trial
AU - Peters, Austin
AU - Verma, Kushagra
AU - Slobodyanyuk, Kseniya
AU - Cheriyan, Thomas
AU - Hoelscher, Christian
AU - Schwab, Frank
AU - Lonner, Baron
AU - Huncke, Tessa
AU - Lafage, Virginie
AU - Errico, Thomas
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.
PY - 2015/4/15
Y1 - 2015/4/15
N2 - Study Design. This is a prospective, randomized, double-blinded comparison of tranexamic acid (TXA), epsilon aminocaproic acid (EACA), and placebo used intraoperatively in patients with adult spinal deformity. Objective. The purpose of this study was to provide high-quality evidence regarding the comparative efficacies of TXA, EACA, and placebo in reducing blood loss and transfusion requirements in patients undergoing posterior spinal fusion surgery. Summary of Background Data. Spine deformity surgery usually involves substantial blood loss. The antifibrinolytics TXA and EACA have been shown to improve hemostasis in large blood loss surgical procedures. Methods. Fifty-one patients undergoing posterior spinal fusion of at least 5 levels for correction of adult spinal deformity were randomized to 1 of 3 treatment groups. Primary outcome measures included intraoperative estimated blood loss, total loss, (estimated blood loss + postoperative blood loss), and transfusion rates. Results. Patients received TXA (n = 19), EACA (n = 19), or placebo (n = 13) in the operating room (mean ages: 60, 47, and 43 yr, respectively); TXA patients were significantly older and had larger estimated blood volumes than both other groups. Total losses were significantly reduced for EACA versus control, and there was a demonstrable but nonsignificant trend toward reduced intraoperative blood loss in both antifibrinolytic arms versus control. EACA had significant reductions in postoperative blood transfusions versus TXA. Conclusion. The findings in this study support the use of antifibrinolytics to reduce blood loss in posterior adult spinal deformity surgery.
AB - Study Design. This is a prospective, randomized, double-blinded comparison of tranexamic acid (TXA), epsilon aminocaproic acid (EACA), and placebo used intraoperatively in patients with adult spinal deformity. Objective. The purpose of this study was to provide high-quality evidence regarding the comparative efficacies of TXA, EACA, and placebo in reducing blood loss and transfusion requirements in patients undergoing posterior spinal fusion surgery. Summary of Background Data. Spine deformity surgery usually involves substantial blood loss. The antifibrinolytics TXA and EACA have been shown to improve hemostasis in large blood loss surgical procedures. Methods. Fifty-one patients undergoing posterior spinal fusion of at least 5 levels for correction of adult spinal deformity were randomized to 1 of 3 treatment groups. Primary outcome measures included intraoperative estimated blood loss, total loss, (estimated blood loss + postoperative blood loss), and transfusion rates. Results. Patients received TXA (n = 19), EACA (n = 19), or placebo (n = 13) in the operating room (mean ages: 60, 47, and 43 yr, respectively); TXA patients were significantly older and had larger estimated blood volumes than both other groups. Total losses were significantly reduced for EACA versus control, and there was a demonstrable but nonsignificant trend toward reduced intraoperative blood loss in both antifibrinolytic arms versus control. EACA had significant reductions in postoperative blood transfusions versus TXA. Conclusion. The findings in this study support the use of antifibrinolytics to reduce blood loss in posterior adult spinal deformity surgery.
KW - MAP
KW - adult spinal deformity
KW - antifibrinolytic
KW - blood loss
KW - epsilon aminocaproic acid
KW - posterior spinal fusion
KW - randomized control
KW - scoliosis
KW - spine surgery
KW - tranexamic acid
KW - transfusion
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U2 - 10.1097/BRS.0000000000000799
DO - 10.1097/BRS.0000000000000799
M3 - Article
C2 - 25868100
AN - SCOPUS:84958178049
SN - 0362-2436
VL - 40
SP - E443-E449
JO - Spine
JF - Spine
IS - 8
ER -