TY - JOUR
T1 - Antigen presentation by MHC class I and its regulation by interferon γ
AU - Früh, Klaus
AU - Yang, Young
PY - 1999/2/1
Y1 - 1999/2/1
N2 - Antigen processing by MHC class I molecules begins with the generation of peptides by proteolytic breakdown of proteins. IFN-γ upregulates gene expression of several proteasomal subunits as well as the proteasome regulator PA28; this implicated their role in antigen degradation. Crystallographic, mutational and biochemical studies contributed to our understanding of the basic principles of proteasomal protein degradation and the consequences of IFN-γ induction for proteasome function. In addition, nonproteasomal mechanisms seem to be involved in antigen degradation. Leucine aminopeptidase, which is also upregulated by IFN-γ, was shown to collaborate with the proteasome for epitope production and unknown proteases seem to compensate for the loss of proteasomal degradation in the presence of proteasome inhibitors. Thus, a rather complex picture emerges for the rules governing peptide production in the presence or absence of IFN-γ.
AB - Antigen processing by MHC class I molecules begins with the generation of peptides by proteolytic breakdown of proteins. IFN-γ upregulates gene expression of several proteasomal subunits as well as the proteasome regulator PA28; this implicated their role in antigen degradation. Crystallographic, mutational and biochemical studies contributed to our understanding of the basic principles of proteasomal protein degradation and the consequences of IFN-γ induction for proteasome function. In addition, nonproteasomal mechanisms seem to be involved in antigen degradation. Leucine aminopeptidase, which is also upregulated by IFN-γ, was shown to collaborate with the proteasome for epitope production and unknown proteases seem to compensate for the loss of proteasomal degradation in the presence of proteasome inhibitors. Thus, a rather complex picture emerges for the rules governing peptide production in the presence or absence of IFN-γ.
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U2 - 10.1016/S0952-7915(99)80014-4
DO - 10.1016/S0952-7915(99)80014-4
M3 - Article
C2 - 10047537
AN - SCOPUS:0038899636
SN - 0952-7915
VL - 11
SP - 76
EP - 81
JO - Current opinion in immunology
JF - Current opinion in immunology
IS - 1
ER -