TY - JOUR
T1 - Antigenic stimulation of active E-rosette-forming lymphocytes in multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis
AU - Offner, H.
AU - Konat, G.
AU - Legg, N. J.
AU - Raun, N. E.
AU - Winterberg, H.
AU - Clausen, J.
PY - 1980/7
Y1 - 1980/7
N2 - Lymphocytes from 73 multiple sclerosis (MS) patients, 58 patients with other neurological diseases (OND), 7 patients with systemic lupus erythematosus (SLE), 34 patients with rheumatoid arthritis (RA), and 10 patients with other diseases were tested for reactivity to brain antigens by the active E-rosette test. Apart from those treated with steroids, all but one of the MS patients, all the SLE patients, and all the RA patients responded to low doses (i.e., 0.1-5 pg total protein) of an acidic extract of MS myelin (MSBP) and of a partially purified protein fraction of MS brain (peak 2). Forty MS patients, one SLE patient, and none of the RA patients responded to an acidic extract of control myelin. Thirty-eight percent of patients with other neurological diseases showed stimulation by both MS and control BP, but none of them responded to MS peak 2 antigen. The results thus indicate a similarity in the response of MS, SLE, and RA patients' lymphocytes to MS brain antigens, but not to normal brain material.
AB - Lymphocytes from 73 multiple sclerosis (MS) patients, 58 patients with other neurological diseases (OND), 7 patients with systemic lupus erythematosus (SLE), 34 patients with rheumatoid arthritis (RA), and 10 patients with other diseases were tested for reactivity to brain antigens by the active E-rosette test. Apart from those treated with steroids, all but one of the MS patients, all the SLE patients, and all the RA patients responded to low doses (i.e., 0.1-5 pg total protein) of an acidic extract of MS myelin (MSBP) and of a partially purified protein fraction of MS brain (peak 2). Forty MS patients, one SLE patient, and none of the RA patients responded to an acidic extract of control myelin. Thirty-eight percent of patients with other neurological diseases showed stimulation by both MS and control BP, but none of them responded to MS peak 2 antigen. The results thus indicate a similarity in the response of MS, SLE, and RA patients' lymphocytes to MS brain antigens, but not to normal brain material.
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U2 - 10.1016/0090-1229(80)90142-7
DO - 10.1016/0090-1229(80)90142-7
M3 - Article
C2 - 7398143
AN - SCOPUS:0018871093
SN - 0090-1229
VL - 16
SP - 367
EP - 373
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 3
ER -