TY - JOUR
T1 - Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols
AU - Gimenez, Valéria M.M.
AU - Alvarenga, Tavane A.
AU - Groppo, Milton
AU - Silva, Márcio L.A.e.
AU - Cunha, Wilson R.
AU - Januário, Ana H.
AU - Smilkstein, Martin J.
AU - Riscoe, Michael K.
AU - Pauletti, Patricia M.
N1 - Funding Information:
The authors thank FAPESP (São Paulo Research Foundation) for financial support (Grant 2013/09280-6 , 2016/10313-4, and 2016/06260-2 ). CNPq (The National Council for Scientific and Technological Development) is acknowledged for Research Productivity Fellowships granted to M.L.A.S., W.R.C., A.H.J., M.G. and P.M.P. T.A.A. and V.M.M.G. were supported by FAPESP (2013/20280-8) and CAPES scholarships.
Funding Information:
The authors thank FAPESP (S?o Paulo Research Foundation) for financial support (Grant 2013/09280-6, 2016/10313-4, and 2016/06260-2). CNPq (The National Council for Scientific and Technological Development) is acknowledged for Research Productivity Fellowships granted to M.L.A.S., W.R.C., A.H.J., M.G. and P.M.P. T.A.A. and V.M.M.G. were supported by FAPESP (2013/20280-8) and CAPES scholarships.
Funding Information:
The authors thank FAPESP (São Paulo Research Foundation) for financial support (Grant 2013/09280-6, 2016/10313-4, and 2016/06260-2). CNPq (The National Council for Scientific and Technological Development) is acknowledged for Research Productivity Fellowships granted to M.L.A.S., W.R.C., A.H.J., M.G. and P.M.P. T.A.A. and V.M.M.G. were supported by FAPESP (2013/20280-8) and CAPES scholarships.
Publisher Copyright:
© 2019 Sociedade Brasileira de Farmacognosia
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The ethanol crude extract from cashew (Anacardium occidentale L. Anacardiaceae) displayed significant antiplasmodial activity (IC50 0.577 μg/ml). Liquid chromatography-high resolution Mass spectrometry analysis was performed to identify the main compounds existing in the ethanol extract. The occurrence of anacardic acids, cardols, and 2-methylcardols derivatives was confirmed in the extract. The IC50 obtained, when the main isolated compounds were evaluated in Plasmodium falciparum D6 strain, ranged from 5.39 μM to >100 μM. Tested here for the first time, the data showed that cardol triene 1 (IC50 = 5.69 μM) and 2-methylcardol triene 4 (IC50 = 5.39 μM) demonstrated good antimalarial activity. In conclusion, Anacardium occidentale nuts presented relevant biological potential, and further studies should be considered.
AB - The ethanol crude extract from cashew (Anacardium occidentale L. Anacardiaceae) displayed significant antiplasmodial activity (IC50 0.577 μg/ml). Liquid chromatography-high resolution Mass spectrometry analysis was performed to identify the main compounds existing in the ethanol extract. The occurrence of anacardic acids, cardols, and 2-methylcardols derivatives was confirmed in the extract. The IC50 obtained, when the main isolated compounds were evaluated in Plasmodium falciparum D6 strain, ranged from 5.39 μM to >100 μM. Tested here for the first time, the data showed that cardol triene 1 (IC50 = 5.69 μM) and 2-methylcardol triene 4 (IC50 = 5.39 μM) demonstrated good antimalarial activity. In conclusion, Anacardium occidentale nuts presented relevant biological potential, and further studies should be considered.
KW - Anacardic acid
KW - Antiplasmodial
KW - Cardol
KW - Cashew
KW - Methylcardol
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U2 - 10.1016/j.bjp.2018.11.003
DO - 10.1016/j.bjp.2018.11.003
M3 - Article
AN - SCOPUS:85058511414
SN - 0102-695X
VL - 29
SP - 36
EP - 39
JO - Revista Brasileira de Farmacognosia
JF - Revista Brasileira de Farmacognosia
IS - 1
ER -