Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols

Valéria M.M. Gimenez, Tavane A. Alvarenga, Milton Groppo, Márcio L.A.e. Silva, Wilson R. Cunha, Ana H. Januário, Martin J. Smilkstein, Michael K. Riscoe, Patricia M. Pauletti

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The ethanol crude extract from cashew (Anacardium occidentale L. Anacardiaceae) displayed significant antiplasmodial activity (IC50 0.577 μg/ml). Liquid chromatography-high resolution Mass spectrometry analysis was performed to identify the main compounds existing in the ethanol extract. The occurrence of anacardic acids, cardols, and 2-methylcardols derivatives was confirmed in the extract. The IC50 obtained, when the main isolated compounds were evaluated in Plasmodium falciparum D6 strain, ranged from 5.39 μM to >100 μM. Tested here for the first time, the data showed that cardol triene 1 (IC50 = 5.69 μM) and 2-methylcardol triene 4 (IC50 = 5.39 μM) demonstrated good antimalarial activity. In conclusion, Anacardium occidentale nuts presented relevant biological potential, and further studies should be considered.

Original languageEnglish (US)
Pages (from-to)36-39
Number of pages4
JournalRevista Brasileira de Farmacognosia
Issue number1
StatePublished - Jan 1 2019


  • Anacardic acid
  • Antiplasmodial
  • Cardol
  • Cashew
  • Methylcardol

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)


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