TY - JOUR
T1 - Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols
AU - Gimenez, Valéria M.M.
AU - Alvarenga, Tavane A.
AU - Groppo, Milton
AU - Silva, Márcio L.A.e.
AU - Cunha, Wilson R.
AU - Januário, Ana H.
AU - Smilkstein, Martin J.
AU - Riscoe, Michael K.
AU - Pauletti, Patricia M.
N1 - Publisher Copyright:
© 2019 Sociedade Brasileira de Farmacognosia
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The ethanol crude extract from cashew (Anacardium occidentale L. Anacardiaceae) displayed significant antiplasmodial activity (IC50 0.577 μg/ml). Liquid chromatography-high resolution Mass spectrometry analysis was performed to identify the main compounds existing in the ethanol extract. The occurrence of anacardic acids, cardols, and 2-methylcardols derivatives was confirmed in the extract. The IC50 obtained, when the main isolated compounds were evaluated in Plasmodium falciparum D6 strain, ranged from 5.39 μM to >100 μM. Tested here for the first time, the data showed that cardol triene 1 (IC50 = 5.69 μM) and 2-methylcardol triene 4 (IC50 = 5.39 μM) demonstrated good antimalarial activity. In conclusion, Anacardium occidentale nuts presented relevant biological potential, and further studies should be considered.
AB - The ethanol crude extract from cashew (Anacardium occidentale L. Anacardiaceae) displayed significant antiplasmodial activity (IC50 0.577 μg/ml). Liquid chromatography-high resolution Mass spectrometry analysis was performed to identify the main compounds existing in the ethanol extract. The occurrence of anacardic acids, cardols, and 2-methylcardols derivatives was confirmed in the extract. The IC50 obtained, when the main isolated compounds were evaluated in Plasmodium falciparum D6 strain, ranged from 5.39 μM to >100 μM. Tested here for the first time, the data showed that cardol triene 1 (IC50 = 5.69 μM) and 2-methylcardol triene 4 (IC50 = 5.39 μM) demonstrated good antimalarial activity. In conclusion, Anacardium occidentale nuts presented relevant biological potential, and further studies should be considered.
KW - Anacardic acid
KW - Antiplasmodial
KW - Cardol
KW - Cashew
KW - Methylcardol
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U2 - 10.1016/j.bjp.2018.11.003
DO - 10.1016/j.bjp.2018.11.003
M3 - Article
AN - SCOPUS:85058511414
SN - 0102-695X
VL - 29
SP - 36
EP - 39
JO - Revista Brasileira de Farmacognosia
JF - Revista Brasileira de Farmacognosia
IS - 1
ER -