Antipsychotic-induced weight gain: A review of the literature

D. B. Allison, D. E. Casey

Research output: Contribution to journalReview articlepeer-review

293 Scopus citations


With the availability of the so-called novel antipsychotic agents, extrapyramidal symptoms are becoming decreasingly problematic for patients with schizophrenia, and simultaneously, a new symptom is emerging as a preeminent concern. This side effect is weight gain and its metabolic concomitants. This article reviews what is currently known about antipsychotic-induced weight gain, describes the magnitude of the problem, briefly touches on mechanisms of action, and addresses the correlation of interindividual variations in magnitude of weight gain. In addition, we address questions about the effects of weight gain on compliance and whether or not there is a correlation between weight gain and therapeutic efficacy. Finally, we address medical consequences of weight gain and review the literature supporting various treatment options for antipsychotic-induced weight gain. As will be seen, this is an area of research in its infancy, and much work remains to be done.

Original languageEnglish (US)
Pages (from-to)22-31
Number of pages10
JournalJournal of Clinical Psychiatry
Issue numberSUPPL. 7
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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