Antiviral drug resistance: Mechanisms and clinical implications

Lynne Strasfeld, Sunwen Chou

Research output: Contribution to journalReview articlepeer-review

118 Scopus citations


Antiviral drug resistance is an increasing concern in immunocompromised patient populations, where ongoing viral replication and prolonged drug exposure lead to the selection of resistant strains. Rapid diagnosis of resistance can be made by associating characteristic viral mutations with resistance to various drugs as determined by phenotypic assays. Management of drug resistance includes optimization of host factors and drug delivery, selection of alternative therapies based on knowledge of mechanisms of resistance, and the development of new antivirals. This article discusses drug resistance in herpesviruses and hepatitis B.

Original languageEnglish (US)
Pages (from-to)413-437
Number of pages25
JournalInfectious Disease Clinics of North America
Issue number2
StatePublished - Jun 2010


  • Cytomegalovirus
  • Drug resistance
  • Hepatitis B virus
  • Herpes simplex virus
  • Transplant
  • Varicella zoster virus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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