apoE isoforms and measures of anxiety in probable AD patients and Apoe -/- mice

Jennifer Robertson, Justine Curley, Jeffrey Kaye, Joseph Quinn, Timothy Pfankuch, Jacob Raber

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoe -/- male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoe -/- mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule-associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with ε4/ε4 showed higher anxiety scores than those with ε3/ε3. We conclude that human apoE isoforms have differential effects on measures of anxiety.

Original languageEnglish (US)
Pages (from-to)637-643
Number of pages7
JournalNeurobiology of Aging
Issue number5
StatePublished - May 2005


  • Alzheimer's disease
  • Amygdala
  • Anxiety
  • MAP-2
  • apoE

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Aging
  • Neuroscience(all)
  • Developmental Biology


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