Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease

Sergio Fazio, Michael D. Shapiro

    Research output: Contribution to journalReview articlepeer-review

    56 Scopus citations


    Cholesterol-rich, apolipoprotein B (apoB)-containing lipoproteins are now widely accepted as the most important causal agents of atherosclerotic cardiovascular disease. Multiple unequivocal and orthogonal lines of evidence all converge on low-density lipoprotein and related particles as being the principal actors in the genesis of atherosclerosis. Here, we review the fundamental role of atherogenic apoB-containing lipoproteins in cardiovascular disease and several other humoral and parietal factors that are required to initiate and maintain arterial degeneration. The biology of foam cells and their interactions with high-density lipoproteins, including cholesterol efflux, are also briefly reviewed.

    Original languageEnglish (US)
    Article number134
    StatePublished - 2017


    • ApoB
    • Apolipoprotein B
    • Arterial degeneration
    • Atherogenic apoB-lipoprotein
    • Atherosclerotic cardiovascular disease
    • Foam cell
    • HDL

    ASJC Scopus subject areas

    • General Immunology and Microbiology
    • General Pharmacology, Toxicology and Pharmaceutics
    • General Biochemistry, Genetics and Molecular Biology


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