Apoptosis in breast cancer

Haim Werner; Youngman Oh; Charles T. Roberts

doi:10.1016/S1566-3124(01)06001-1

Apoptosis in breast cancer

Haim Werner
, Youngman Oh
, Charles T. Roberts

Oregon National Primate Research Center

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

It has become increasingly clear that apoptosis plays a critical role in mammary gland development and is an important facet of mammary carcinogenesis. The critical role of apoptosis in breast cancer derives from: (1) the influence of BRCA and p53 mutations that result in continued proliferation and increased genetic instability in precancerous mammary epithelial cells that would otherwise be subject to growth arrest and/or apoptotic death: (2) the apoptosis-modulating effects of many hormones and growth factors that had independently been demonstrated to influence breast cancer development and progression; and (3) the potential diagnostic value of factors such as IGF-I and Bcl-2, whose predictive value may reflect their anti-apoptotic effects. The continuing elucidation of the molecular pathways involved in apoptosis and their regulatory mechanisms will provide new avenues for improved diagnosis and treatment of breast cancer.

Original language	English (US)
Pages (from-to)	1-22
Number of pages	22
Journal	Advances in Cell Aging and Gerontology
Volume	6
Issue number	C
DOIs	https://doi.org/10.1016/S1566-3124(01)06001-1
State	Published - 2001

Funding

Work in the laboratory of H.W. is supported by grants from the Israel Cancer Association, The Israel Academy of Sciences, The U.S.-Israel Binational Science Foundation, The Recanati Foundation, The Israel Cancer Research Fund (New York) and the Fogarty International Center (NIH, USA). H.W. is the recipient of a Guastalla Fellowship from the Rashi Foundation, Israel. Work in the laboratory of Y.O. is supprted by grants from the U.S. Department of Defense and the American Cancer Society. Work in the laboratory of C.T.R. is supported by grants from the NIDDK, the NICHD, the Fogarty International Center (NIH), and the M.J. Murdock Charitable Trust.

Funders
Rashi Foundation, Israel
Recanati Foundation
U.S.-Israel Binational Science Foundation
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
U.S. Department of Defense
American Cancer Society-Stanford Cancer Institute
Fogarty International Center
National Institute of Diabetes and Digestive and Kidney Diseases
M.J. Murdock Charitable Trust
Israel Cancer Research Fund
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Israel Academy of Sciences and Humanities
Israel Cancer Association

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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10.1016/S1566-3124(01)06001-1

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@article{4f9961d2bdf24cebb67ebeed8b973820,

title = "Apoptosis in breast cancer",

abstract = "It has become increasingly clear that apoptosis plays a critical role in mammary gland development and is an important facet of mammary carcinogenesis. The critical role of apoptosis in breast cancer derives from: (1) the influence of BRCA and p53 mutations that result in continued proliferation and increased genetic instability in precancerous mammary epithelial cells that would otherwise be subject to growth arrest and/or apoptotic death: (2) the apoptosis-modulating effects of many hormones and growth factors that had independently been demonstrated to influence breast cancer development and progression; and (3) the potential diagnostic value of factors such as IGF-I and Bcl-2, whose predictive value may reflect their anti-apoptotic effects. The continuing elucidation of the molecular pathways involved in apoptosis and their regulatory mechanisms will provide new avenues for improved diagnosis and treatment of breast cancer.",

author = "Haim Werner and Youngman Oh and Roberts, \{Charles T.\}",

note = "Funding Information: Work in the laboratory of H.W. is supported by grants from the Israel Cancer Association, The Israel Academy of Sciences, The U.S.-Israel Binational Science Foundation, The Recanati Foundation, The Israel Cancer Research Fund (New York) and the Fogarty International Center (NIH, USA). H.W. is the recipient of a Guastalla Fellowship from the Rashi Foundation, Israel. Work in the laboratory of Y.O. is supprted by grants from the U.S. Department of Defense and the American Cancer Society. Work in the laboratory of C.T.R. is supported by grants from the NIDDK, the NICHD, the Fogarty International Center (NIH), and the M.J. Murdock Charitable Trust.",

year = "2001",

doi = "10.1016/S1566-3124(01)06001-1",

language = "English (US)",

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pages = "1--22",

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}

TY - JOUR

T1 - Apoptosis in breast cancer

AU - Werner, Haim

AU - Oh, Youngman

AU - Roberts, Charles T.

N1 - Funding Information: Work in the laboratory of H.W. is supported by grants from the Israel Cancer Association, The Israel Academy of Sciences, The U.S.-Israel Binational Science Foundation, The Recanati Foundation, The Israel Cancer Research Fund (New York) and the Fogarty International Center (NIH, USA). H.W. is the recipient of a Guastalla Fellowship from the Rashi Foundation, Israel. Work in the laboratory of Y.O. is supprted by grants from the U.S. Department of Defense and the American Cancer Society. Work in the laboratory of C.T.R. is supported by grants from the NIDDK, the NICHD, the Fogarty International Center (NIH), and the M.J. Murdock Charitable Trust.

PY - 2001

Y1 - 2001

N2 - It has become increasingly clear that apoptosis plays a critical role in mammary gland development and is an important facet of mammary carcinogenesis. The critical role of apoptosis in breast cancer derives from: (1) the influence of BRCA and p53 mutations that result in continued proliferation and increased genetic instability in precancerous mammary epithelial cells that would otherwise be subject to growth arrest and/or apoptotic death: (2) the apoptosis-modulating effects of many hormones and growth factors that had independently been demonstrated to influence breast cancer development and progression; and (3) the potential diagnostic value of factors such as IGF-I and Bcl-2, whose predictive value may reflect their anti-apoptotic effects. The continuing elucidation of the molecular pathways involved in apoptosis and their regulatory mechanisms will provide new avenues for improved diagnosis and treatment of breast cancer.

AB - It has become increasingly clear that apoptosis plays a critical role in mammary gland development and is an important facet of mammary carcinogenesis. The critical role of apoptosis in breast cancer derives from: (1) the influence of BRCA and p53 mutations that result in continued proliferation and increased genetic instability in precancerous mammary epithelial cells that would otherwise be subject to growth arrest and/or apoptotic death: (2) the apoptosis-modulating effects of many hormones and growth factors that had independently been demonstrated to influence breast cancer development and progression; and (3) the potential diagnostic value of factors such as IGF-I and Bcl-2, whose predictive value may reflect their anti-apoptotic effects. The continuing elucidation of the molecular pathways involved in apoptosis and their regulatory mechanisms will provide new avenues for improved diagnosis and treatment of breast cancer.

UR - https://www.scopus.com/pages/publications/35448964294

UR - https://www.scopus.com/pages/publications/35448964294#tab=citedBy

U2 - 10.1016/S1566-3124(01)06001-1

DO - 10.1016/S1566-3124(01)06001-1

M3 - Review article

AN - SCOPUS:35448964294

SN - 1566-3124

VL - 6

SP - 1

EP - 22

JO - Advances in Cell Aging and Gerontology

JF - Advances in Cell Aging and Gerontology

IS - C

ER -

Apoptosis in breast cancer

Abstract

Funding

ASJC Scopus subject areas

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