Application of color doppler ultrasonography in early gallbladder cancer: A case report

M. Shirahama, K. Takahashi, K. Kishikawa, E. Sasatomi, Y. Miyamoto, H. Ishibashi

Research output: Contribution to journalArticlepeer-review


A 70-year-old man was admitted to the hospital because of an elevated lesion of the gallbladder (GB). Initial laboratory examination showed mild abnormality in liver function and slight hyperglycemia. Gray-scale ultrasonography (US) showed a small elevated lesion on a papillary surface at the fundus of the GB, and the adjacent GB wall was mildly thickened. Color Doppler US demonstrated several blood flow signals at the base of the elevated lesion, and the power Doppler mode detected the blood flow signals more sensitively, not only in the underlying GB wall but in the wall contiguous to the lesion as well. Color Doppler signals in the normal GB wall were invisible. Analysis of the Doppler waveform demonstrated arterial blood flow signals. A resected GB specimen showed papillary adenocarcinoma (early cancer) and dysplastic epithelium in the adjacent area. Immunostaining with factor VIII showed the number of vessels in the GB wall to be the same at the base of the tumor as that in the area of the dysplastic or normal mucosa. Color Doppler and other US examinations seemed to be useful in the detection of early GB cancer.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalJapanese Journal of Medical Ultrasonics
Issue number11
StatePublished - 1998
Externally publishedYes


  • Color Doppler ultrasonography
  • Early cancer
  • Gallbladder cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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