Application of GRADE in systematic reviews: Necessity, frequently-asked questions and concerns

Yao Long Chen; Liang Yao; Norris Susan; Liang Du; Hao Chen; Xian Tao Zeng; Zhi Mao; Ke Hu Yang

doi:10.7507/1672-2531.20130240

Application of GRADE in systematic reviews: Necessity, frequently-asked questions and concerns

Yao Long Chen, Liang Yao, Norris Susan, Liang Du, Hao Chen, Xian Tao Zeng, Zhi Mao, Ke Hu Yang

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

We elaborated the reasons why systematic reviews need to use GRADE based on a couple of specific examples. Aiming to provide references to understand and use GRADE correctly, we also answered some frequently-asked questions and concerns about GRADE as follows: a) differentiating the uses of GRADE between its application in guidelines and in systematic reviews; b) how to determine the overall quality of evidence? c) can GRADE be used to access the quality of single study or not? d) different uses of GRADE between randomized controlled trials (RCTs) and observational studies; e) weight of GRADE items; and f) factors that might influence the results of GRADE and the balance between upgrading and downgrading.

Original language	English (US)
Pages (from-to)	1401-1404
Number of pages	4
Journal	Chinese Journal of Evidence-Based Medicine
Volume	13
Issue number	12
DOIs	https://doi.org/10.7507/1672-2531.20130240
State	Published - 2013
Externally published	Yes

Keywords

GRADE
Grading Evidence
Systematic review

ASJC Scopus subject areas

General Medicine

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10.7507/1672-2531.20130240

Cite this

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AU - Susan, Norris

AU - Du, Liang

AU - Chen, Hao

AU - Zeng, Xian Tao

AU - Mao, Zhi

AU - Yang, Ke Hu

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AB - We elaborated the reasons why systematic reviews need to use GRADE based on a couple of specific examples. Aiming to provide references to understand and use GRADE correctly, we also answered some frequently-asked questions and concerns about GRADE as follows: a) differentiating the uses of GRADE between its application in guidelines and in systematic reviews; b) how to determine the overall quality of evidence? c) can GRADE be used to access the quality of single study or not? d) different uses of GRADE between randomized controlled trials (RCTs) and observational studies; e) weight of GRADE items; and f) factors that might influence the results of GRADE and the balance between upgrading and downgrading.

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Application of GRADE in systematic reviews: Necessity, frequently-asked questions and concerns

Abstract

Keywords

ASJC Scopus subject areas

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