Approaches to identify, clone, and express symbiont bioactive metabolite genes

Mark Hildebrand; Laura E. Waggoner; Grace E. Lim; Katherine H. Sharp; Christian P. Ridley; Margo G. Haygood

doi:10.1039/b302336m

Approaches to identify, clone, and express symbiont bioactive metabolite genes

Mark Hildebrand, Laura E. Waggoner, Grace E. Lim, Katherine H. Sharp, Christian P. Ridley, Margo G. Haygood

Research output: Contribution to journal › Review article › peer-review

85 Scopus citations

Abstract

This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

Original language	English (US)
Pages (from-to)	122-142
Number of pages	21
Journal	Natural Product Reports
Volume	21
Issue number	1
DOIs	https://doi.org/10.1039/b302336m
State	Published - Feb 2004
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1039/b302336m

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abstract = "This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.",

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AU - Hildebrand, Mark

AU - Waggoner, Laura E.

AU - Lim, Grace E.

AU - Sharp, Katherine H.

AU - Ridley, Christian P.

AU - Haygood, Margo G.

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N2 - This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

AB - This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

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Approaches to identify, clone, and express symbiont bioactive metabolite genes

Abstract

ASJC Scopus subject areas

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