Approaches to identify, clone, and express symbiont bioactive metabolite genes

Mark Hildebrand, Laura E. Waggoner, Grace E. Lim, Katherine H. Sharp, Christian P. Ridley, Margo G. Haygood

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

Original languageEnglish (US)
Pages (from-to)122-142
Number of pages21
JournalNatural Product Reports
Issue number1
StatePublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'Approaches to identify, clone, and express symbiont bioactive metabolite genes'. Together they form a unique fingerprint.

Cite this