Are proteasomes involved in the formation of the kinetochore?

N. Paweletz, C. Wójcik, D. Schroeter, E. M. Finze

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Proteasomes catalyse the degradation of proteins responsible for the regulation of mitosis enabling the cell to complete cell division. We have studied the effect of an inhibitor of the chymotrypsin-like activity of the proteasome on the trilaminar structure of the kinetochore in HeLa cells. Whereas a role for the proteasome in the degeneration of the kinetochore was predicted, we found instead that the inhibitor strongly retarded kinetochore development. We observed different 'developmental' stages of the kinetochore from the fibrous ball of a 'prekinetochore' to the 'mature' kinetochore in one cell. The data presented here support the proposition that proteasomes are involved in kinetochore formation.

Original languageEnglish (US)
Pages (from-to)436-442
Number of pages7
JournalChromosome Research
Issue number6
StatePublished - 1996
Externally publishedYes


  • Cell cycle regulation
  • Centromere
  • Kinetochore
  • Microtubules
  • Mitosis
  • Proteasomes

ASJC Scopus subject areas

  • Genetics


Dive into the research topics of 'Are proteasomes involved in the formation of the kinetochore?'. Together they form a unique fingerprint.

Cite this