TY - JOUR
T1 - Arterial stiffness, central pressures, and incident hospitalized heart failure in the chronic renal insufficiency cohort study
AU - Chirinos, Julio A.
AU - Khan, Abigail
AU - Bansal, Nisha
AU - Dries, Daniel L.
AU - Feldman, Harold I.
AU - Ford, Virginia
AU - Anderson, Amanda H.
AU - Kallem, Radhakrishna
AU - Lash, James P.
AU - Ojo, Akinlolu
AU - Schreiber, Martin
AU - Sheridan, Angela
AU - Strelsin, Jillian
AU - Teal, Valerie
AU - Roy, Jason
AU - Pan, Qiang
AU - Go, Alan S.
AU - Townsend, Raymond R.
N1 - Publisher Copyright:
© 2014 American Heart Association, Inc.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Background-Chronic kidney disease is associated with an increased risk of heart failure (HF). We aimed to evaluate the role of large artery stiffness, brachial, and central blood pressure as predictors of incident hospitalized HF in the Chronic Renal Insufficiency Cohort (CRIC), a multiethnic, multicenter prospective observational study of patients with chronic kidney disease. Methods and Results-We studied 2602 participants who were free of HF at baseline. Carotid-femoral pulse wave velocity (CF-PWV; the gold standard index of large artery stiffness), brachial, and central pressures (estimated via radial tonometry and a generalized transfer function) were assessed at baseline. Participants were prospectively followed up to assess the development of new-onset hospitalized HF. During 3.5 years of follow-up, 154 participants had a first hospital admission for HF. CF-PWV was a significant independent predictor of incident hospitalized HF. When compared with the lowest tertile, the hazard ratios among subjects in the middle and top CF-PWV tertiles were 2.33 (95% confidence interval, 1.37-3.97; P=0.002) and 5.24 (95% confidence interval, 3.22-8.53; P<0.0001), respectively. After adjustment for multiple confounders, the hazard ratios for the middle and top CF-PWV tertiles were 1.95 (95% confidence interval, 0.92-4.13; P=0.079) and 3.01 (95% confidence interval, 1.45-6.26; P=0.003), respectively. Brachial systolic and pulse pressure were also independently associated with incident hospitalized HF, whereas central pressures were less consistently associated with this end point. The association between CF-PWV and incident HF persisted after adjustment for systolic blood pressure. Conclusions-Large artery stiffness is an independent predictor of incident HF in chronic kidney disease, an association with strong biological plausibility given the known effects of large artery stiffening of left ventricular pulsatile load.
AB - Background-Chronic kidney disease is associated with an increased risk of heart failure (HF). We aimed to evaluate the role of large artery stiffness, brachial, and central blood pressure as predictors of incident hospitalized HF in the Chronic Renal Insufficiency Cohort (CRIC), a multiethnic, multicenter prospective observational study of patients with chronic kidney disease. Methods and Results-We studied 2602 participants who were free of HF at baseline. Carotid-femoral pulse wave velocity (CF-PWV; the gold standard index of large artery stiffness), brachial, and central pressures (estimated via radial tonometry and a generalized transfer function) were assessed at baseline. Participants were prospectively followed up to assess the development of new-onset hospitalized HF. During 3.5 years of follow-up, 154 participants had a first hospital admission for HF. CF-PWV was a significant independent predictor of incident hospitalized HF. When compared with the lowest tertile, the hazard ratios among subjects in the middle and top CF-PWV tertiles were 2.33 (95% confidence interval, 1.37-3.97; P=0.002) and 5.24 (95% confidence interval, 3.22-8.53; P<0.0001), respectively. After adjustment for multiple confounders, the hazard ratios for the middle and top CF-PWV tertiles were 1.95 (95% confidence interval, 0.92-4.13; P=0.079) and 3.01 (95% confidence interval, 1.45-6.26; P=0.003), respectively. Brachial systolic and pulse pressure were also independently associated with incident hospitalized HF, whereas central pressures were less consistently associated with this end point. The association between CF-PWV and incident HF persisted after adjustment for systolic blood pressure. Conclusions-Large artery stiffness is an independent predictor of incident HF in chronic kidney disease, an association with strong biological plausibility given the known effects of large artery stiffening of left ventricular pulsatile load.
KW - Heart failure
KW - Pulse wave analysis
KW - Renal insufficiency chronic
KW - Vascular stiffness
UR - https://www.scopus.com/pages/publications/84918533396
UR - https://www.scopus.com/pages/publications/84918533396#tab=citedBy
U2 - 10.1161/CIRCHEARTFAILURE.113.001041
DO - 10.1161/CIRCHEARTFAILURE.113.001041
M3 - Article
C2 - 25059422
AN - SCOPUS:84918533396
SN - 1941-3289
VL - 7
SP - 709
EP - 716
JO - Circulation: Heart Failure
JF - Circulation: Heart Failure
IS - 5
ER -