Assessing genetic‐based therapies for AIDS using the simian immunodeficiency virus

Carla L. Endres; Eric Bergquam; Michael K. Axthelm; Scott W. Wong

doi:10.1111/j.1600-0684.1995.tb00159.x

Assessing genetic‐based therapies for AIDS using the simian immunodeficiency virus

Carla L. Endres, Eric Bergquam, Michael K. Axthelm, Scott W. Wong

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Abstract: A plasmid encoding the full‐length infectious molecular proviral clone of SIV_mac239 was generated. Virus derived from cells transfected with this clone replicated to high levels and was cytopathic for some transformed human CD4⁺ cell lines and primary rhesus macaque peripheral blood mononuclear cells. Since replication of SIV requires the functional expression of the viral encoded rev protein, transient co‐transfection studies were initiated with the infectious proviral clone and a well‐characterized trans‐dominant negative HIV‐1 rev mutant. 1995 Munksgaard

Original language	English (US)
Pages (from-to)	141-144
Number of pages	4
Journal	Journal of medical primatology
Volume	24
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0684.1995.tb00159.x
State	Published - May 1995

Keywords

HIV
SIV
antiviral
gene therapy
retrovirus
transient transfection

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1111/j.1600-0684.1995.tb00159.x

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title = "Assessing genetic‐based therapies for AIDS using the simian immunodeficiency virus",

abstract = "Abstract: A plasmid encoding the full‐length infectious molecular proviral clone of SIVmac239 was generated. Virus derived from cells transfected with this clone replicated to high levels and was cytopathic for some transformed human CD4+ cell lines and primary rhesus macaque peripheral blood mononuclear cells. Since replication of SIV requires the functional expression of the viral encoded rev protein, transient co‐transfection studies were initiated with the infectious proviral clone and a well‐characterized trans‐dominant negative HIV‐1 rev mutant. 1995 Munksgaard",

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author = "Endres, {Carla L.} and Eric Bergquam and Axthelm, {Michael K.} and Wong, {Scott W.}",

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T1 - Assessing genetic‐based therapies for AIDS using the simian immunodeficiency virus

AU - Endres, Carla L.

AU - Bergquam, Eric

AU - Axthelm, Michael K.

AU - Wong, Scott W.

PY - 1995/5

Y1 - 1995/5

N2 - Abstract: A plasmid encoding the full‐length infectious molecular proviral clone of SIVmac239 was generated. Virus derived from cells transfected with this clone replicated to high levels and was cytopathic for some transformed human CD4+ cell lines and primary rhesus macaque peripheral blood mononuclear cells. Since replication of SIV requires the functional expression of the viral encoded rev protein, transient co‐transfection studies were initiated with the infectious proviral clone and a well‐characterized trans‐dominant negative HIV‐1 rev mutant. 1995 Munksgaard

AB - Abstract: A plasmid encoding the full‐length infectious molecular proviral clone of SIVmac239 was generated. Virus derived from cells transfected with this clone replicated to high levels and was cytopathic for some transformed human CD4+ cell lines and primary rhesus macaque peripheral blood mononuclear cells. Since replication of SIV requires the functional expression of the viral encoded rev protein, transient co‐transfection studies were initiated with the infectious proviral clone and a well‐characterized trans‐dominant negative HIV‐1 rev mutant. 1995 Munksgaard

KW - HIV

KW - SIV

KW - antiviral

KW - gene therapy

KW - retrovirus

KW - transient transfection

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Assessing genetic‐based therapies for AIDS using the simian immunodeficiency virus

Abstract

Keywords

ASJC Scopus subject areas

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