TY - JOUR
T1 - Assignment of the chromogranin a (chga) locus to homologous regions on mouse chromosome 12 and rat chromosome 6
AU - Simon-Chazottes, Dominique
AU - Wu, Hongjiang
AU - Parmer, Robert J.
AU - Rozansky, David J.
AU - Szpirer, Josiane
AU - Levan, Goran
AU - Kurtz, Theodore W.
AU - Szpirer, Claude
AU - Guenet, Jean Louis
AU - O'Connor, Daniel T.
PY - 1993/7
Y1 - 1993/7
N2 - Chromogranin A is an acidic protein, stored and released with catecholamines, and is overexpressed in genetic hypertension. In the human genome, its locus has previously been positioned on the long arm of Chromosome 14 in the 14q32 region. As a first step toward evaluating its potential linkage with hereditary hypertension, we determined its chromosomal position in mouse and rat. Chromogranin A was present as a single-copy gene in both mouse and rat. Analysis of the allele distribution in an interspecific mouse backcross by single-strand conformation polymorphism positioned the chromogranin A locus on Chromosome 12, between Igh-C and D12Pas1. Evaluation of a rat/mouse somatic cell hybrid panel indicated that, chromogranin A is on rat Chromosome 6. In each case (mouse, rat, and human), chromogranin A is in a conserved region with nearby markers including the immunoglobulin heavy chain locus.
AB - Chromogranin A is an acidic protein, stored and released with catecholamines, and is overexpressed in genetic hypertension. In the human genome, its locus has previously been positioned on the long arm of Chromosome 14 in the 14q32 region. As a first step toward evaluating its potential linkage with hereditary hypertension, we determined its chromosomal position in mouse and rat. Chromogranin A was present as a single-copy gene in both mouse and rat. Analysis of the allele distribution in an interspecific mouse backcross by single-strand conformation polymorphism positioned the chromogranin A locus on Chromosome 12, between Igh-C and D12Pas1. Evaluation of a rat/mouse somatic cell hybrid panel indicated that, chromogranin A is on rat Chromosome 6. In each case (mouse, rat, and human), chromogranin A is in a conserved region with nearby markers including the immunoglobulin heavy chain locus.
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U2 - 10.1006/geno.1993.1316
DO - 10.1006/geno.1993.1316
M3 - Article
C2 - 8406464
AN - SCOPUS:0027272571
SN - 0888-7543
VL - 17
SP - 252
EP - 255
JO - Genomics
JF - Genomics
IS - 1
ER -