TY - JOUR
T1 - Association between obesity and combination antiretroviral therapy (cART) adherence among persons with early-stage HIV infection initiating cART
AU - on behalf of the META team
AU - Musinguzi, Nicholas
AU - Stanford, Fatima Cody
AU - Boatin, Adeline A.
AU - Orrell, Catherine
AU - Asiimwe, Stephen
AU - Siedner, Mark
AU - Haberer, Jessica E.
AU - Bwana, Bosco M.
AU - Amanyire, Gideon
AU - Matthews, Lynn T.
AU - Tsai, Alexander C.
AU - Katz, Ingrid T.
AU - Bell, Kathleen
AU - Kembabazi, Annet
AU - Mugisha, Stephen
AU - Kibirige, Victoria
AU - Cross, Anna
AU - Kelly, Nicola
AU - Hedt-Gauthier, Bethany
AU - Bangsberg, David R.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2021/8
Y1 - 2021/8
N2 - Background: Obesity is common among people living with HIV (PLWH) and early-stage infection, yet associations with combination antiretroviral (cART) adherence are unclear. Methods: Among PLWH initiating cART in Uganda and South Africa, body mass index (BMI) was assessed at cART initiation, and cART adherence was monitored in real-time over 12 months. The association of obesity (BMI ≥ 30 kg/m2) with adherence was assessed among nonpregnant participants with CD4 > 350 cells/mm3 using fractional regression modeling. Results: Among 322 participants, median age was 32 years, 70% were female, and 54% were from Uganda. Prevalence of obesity was 12% in Uganda and 28% in South Africa. Mean overall cART adherence was 83% in Uganda and 66% in South Africa. Participants with obesity had higher adherence than those without obesity: +3.6% (p = 0.44) in Uganda and +11.4% (p = 0.02) in South Africa. Conclusion: Obesity at cART initiation was common and associated with higher adherence, although only significantly in South Africa.
AB - Background: Obesity is common among people living with HIV (PLWH) and early-stage infection, yet associations with combination antiretroviral (cART) adherence are unclear. Methods: Among PLWH initiating cART in Uganda and South Africa, body mass index (BMI) was assessed at cART initiation, and cART adherence was monitored in real-time over 12 months. The association of obesity (BMI ≥ 30 kg/m2) with adherence was assessed among nonpregnant participants with CD4 > 350 cells/mm3 using fractional regression modeling. Results: Among 322 participants, median age was 32 years, 70% were female, and 54% were from Uganda. Prevalence of obesity was 12% in Uganda and 28% in South Africa. Mean overall cART adherence was 83% in Uganda and 66% in South Africa. Participants with obesity had higher adherence than those without obesity: +3.6% (p = 0.44) in Uganda and +11.4% (p = 0.02) in South Africa. Conclusion: Obesity at cART initiation was common and associated with higher adherence, although only significantly in South Africa.
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U2 - 10.1038/s41366-021-00837-y
DO - 10.1038/s41366-021-00837-y
M3 - Article
C2 - 34007011
AN - SCOPUS:85111467810
SN - 0307-0565
VL - 45
SP - 1855
EP - 1859
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 8
ER -