Asynchronous regional brain volume losses in presymptomatic to moderate AD

J. A. Kaye, M. M. Moore, A. Dame, J. Quinn, R. Camicioli, Diane Howieson, E. Corbridge, B. Care, Gary Nesbit, G. Sexton

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


To determine if rates and locations of brain volume loss associated with AD are phase-specific, occurring prior to clinical onset and at later stages, we performed longitudinal volumetric MRI analysis on 155 subjects enrolled in a prospective study of aging and dementia. Subjects were divided by Clinical Dementia Rating (CDR) scale into stages of Normal (CDR 0 → 0), Very Mild (CDR 0 → 0.5 and 0.5 → 0.5), Mild (CDR 0.5 → 1.0 and 1.0 → 1.0) and Moderate (CDR 1.0 → 2.0 and 2.0 → 2.0) dementia. Rates of volume change in CSF spaces, lobar and medial temporal lobe regions were analyzed for group differences across stages. Annual rates of ventricular volume change differed between non-demented and very mild group (p<0.01). In later severity stages, ventricular, temporal, basal ganglia-thalamic region and total volumes show change. Rates of volume loss increase as dementia progresses, but not uniformly in all regions. These regional and phase-specific volume changes form targets for monitoring disease-modifying therapies at clinically relevant, defined stages of dementia.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalJournal of Alzheimer's Disease
Issue number1
StatePublished - 2005


  • Aging
  • Alzheimer disease
  • Dementia
  • MRI
  • Oldest-old

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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