Auranofin: 1 mg or 9 mg? The search for the appropriate dose

A. Calin, D. Saunders, R. Bennett

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Auranofin (AF) was given to 2 groups of patients, one receiving 1 mg daily (56 patients), the other 9 mg (60 patients) in a double-blind manner. Significantly fewer patients on 1 mg (7%) reduced dosage or dropped out because of side effects than did those on high dose (27%; p < 0.05). Dropouts related to skin rash while dose reduction was necessitated by self-limiting diarrhea. Significantly more patients on low dose dropped out because of lack of efficacy than did those on high dose.

Original languageEnglish (US)
Pages (from-to)146-148
Number of pages3
JournalJournal of Rheumatology
Issue numberSuppl. 8
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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