Autism spectrum disorders associated with X chromosome markers in French-Canadian males

J. Gauthier; R. Joober; M. P. Dubé; J. St-Onge; A. Bonnel; D. Gariépy; S. Laurent; R. Najafee; H. Lacasse; L. St-Charles; É Fombonne; L. Mottron; G. A. Rouleau

doi:10.1038/sj.mp.4001756

Autism spectrum disorders associated with X chromosome markers in French-Canadian males

J. Gauthier, R. Joober, M. P. Dubé, J. St-Onge, A. Bonnel, D. Gariépy, S. Laurent, R. Najafee, H. Lacasse, L. St-Charles, É Fombonne, L. Mottron, G. A. Rouleau

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P = 0.026) and DXS8043 (P = 0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value = 0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.

Original language	English (US)
Pages (from-to)	206-213
Number of pages	8
Journal	Molecular Psychiatry
Volume	11
Issue number	2
DOIs	https://doi.org/10.1038/sj.mp.4001756
State	Published - Feb 2006
Externally published	Yes

Keywords

Association study
Autism spectrum disorders
French-Canadian
Haplotype analysis
X chromosome

ASJC Scopus subject areas

Molecular Biology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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title = "Autism spectrum disorders associated with X chromosome markers in French-Canadian males",

abstract = "It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P = 0.026) and DXS8043 (P = 0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value = 0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.",

keywords = "Association study, Autism spectrum disorders, French-Canadian, Haplotype analysis, X chromosome",

author = "J. Gauthier and R. Joober and Dub{\'e}, {M. P.} and J. St-Onge and A. Bonnel and D. Gari{\'e}py and S. Laurent and R. Najafee and H. Lacasse and L. St-Charles and {\'E} Fombonne and L. Mottron and Rouleau, {G. A.}",

note = "Funding Information: We thank all the families who made this research possible by participating in our study. Claude Marineau and Dr Lan Xiong for helpful discussions and comments. Thanks to Dominique Verlaan for carefully reading the manuscript. We also thank Daniel Rochefort for technical help. This work was supported by the Canadian Institutes for Health Research.",

year = "2006",

month = feb,

doi = "10.1038/sj.mp.4001756",

language = "English (US)",

volume = "11",

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AU - Gauthier, J.

AU - Joober, R.

AU - Dubé, M. P.

AU - St-Onge, J.

AU - Bonnel, A.

AU - Gariépy, D.

AU - Laurent, S.

AU - Najafee, R.

AU - Lacasse, H.

AU - St-Charles, L.

AU - Fombonne, É

AU - Mottron, L.

AU - Rouleau, G. A.

N1 - Funding Information: We thank all the families who made this research possible by participating in our study. Claude Marineau and Dr Lan Xiong for helpful discussions and comments. Thanks to Dominique Verlaan for carefully reading the manuscript. We also thank Daniel Rochefort for technical help. This work was supported by the Canadian Institutes for Health Research.

PY - 2006/2

Y1 - 2006/2

N2 - It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P = 0.026) and DXS8043 (P = 0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value = 0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.

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KW - Haplotype analysis

KW - X chromosome

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Autism spectrum disorders associated with X chromosome markers in French-Canadian males

Abstract

Keywords

ASJC Scopus subject areas

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