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Automated computational inference of multi-protein assemblies from biochemical co-purification data

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Biology has amassed a wealth of information about the function of a multitude of protein-coding genes across species. The challenge now is to understand how all these proteins work together to form a living organism, and a crucial step for gaining this knowledge is a complete description of the molecular “wiring circuits” that underlie cellular processes. In this chapter, we describe a general computational framework for predicting multi-protein assemblies from biochemical co-fractionation data.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages391-399
Number of pages9
DOIs
StatePublished - 2018
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1764
ISSN (Print)1064-3745

Keywords

  • Bioinformatics
  • Cytoscape
  • Docker
  • Machine learning
  • Protein complex prediction
  • Protein interaction prediction
  • Protein-protein interaction
  • Python
  • Systems biology

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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