@article{f08f4563ae5f41aebeaeb987fb0bbf14,
title = "Automated drusen detection in dry age-related macular degeneration by multiple-depth, en face optical coherence tomography",
abstract = "We introduce a method to automatically detect drusen in dry age-related macular degeneration (AMD) from optical coherence tomography with minimum need for layer segmentation. The method is based on the en face detection of drusen areas in C-scans at certain distances above the Bruch{\textquoteright}s membrane, circumventing the difficult task of pathologic retinal pigment epithelium segmentation. All types of drusen can be detected, including the challenging subretinal drusenoid deposits (pseudodrusen). The high sensitivity and accuracy demonstrated here shows its potential for detection of drusen onset in early AMD.",
author = "Rui Zhao and Acner Camino and Jie Wang and Hagag, {Ahmed M.} and Yansha Lu and Bailey, {Steven T.} and Flaxel, {Christina J.} and Hwang, {Thomas S.} and David Huang and Dengwang Li and Yali Jia",
note = "Funding Information: This work was supported by grants R01 EY024544, R01EY027833, DP3 DK104397, P30 EY010572 from the National Institutes of Health (Bethesda, MD), National Natural Science Foundation of China (NO. 61471226), Natural Science Foundation for Distinguished Young Scholars of Shandong Province (NO. JQ201516), China Scholarship Council, China (grant no.: 201608370107) and an unrestricted departmental funding grant and William & Mary Greve Special Scholar Award from Research to Prevent Blindness (New York, NY). The authors also thank the supporting of Taishan scholar project of Shandong Province. Publisher Copyright: {\textcopyright} 2017 Optical Society of America.",
year = "2017",
month = nov,
day = "1",
doi = "10.1364/BOE.8.005049",
language = "English (US)",
volume = "8",
pages = "5049--5064",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "11",
}