Autopsy findings in aids patients with mycobacterium avium complex bacteremia

Francesca J. Torriani; J. Allen Mc Cutchan; Samuel A. Bozzette; Marjorie R. Grafe; Diane V. Havlir

doi:10.1093/infdis/170.6.1601

Autopsy findings in aids patients with mycobacterium avium complex bacteremia

Francesca J. Torriani
, J. Allen Mc Cutchan
, Samuel A. Bozzette
, Marjorie R. Grafe
, Diane V. Havlir

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence ofMAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.

Original language	English (US)
Pages (from-to)	1601-1605
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	170
Issue number	6
DOIs	https://doi.org/10.1093/infdis/170.6.1601
State	Published - Dec 1994
Externally published	Yes

Funding

Received 24 March 1994: revised 24 June 1994. Presented in part: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, 16 October 1993 (abstract 1406). Human experimentation guidelines of the US Department of Health and Human Services were followed and this work was reviewed and approved by the Institutional Review Board (School of Medicine) of the University of California, San Diego. Financial support: California Universitywide AIDS Research Program through the California Collaborative Treatment Group (CCTG): Swiss National Foundation for AIDS Research (92-7096). Reprints or correspondence: Dr. D. Havlir, UCSD Treatment Center, 2760 Fifth Ave.. Suite 300, San Diego. CA 92103. Present affiliation: Department of Pathology, University of Texas, Medical Branch, Galveston.

Funders	Funder number
California Universitywide AIDS Research Program
Swiss National Foundation for AIDS Research	92-7096

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/170.6.1601

Cite this

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title = "Autopsy findings in aids patients with mycobacterium avium complex bacteremia",

abstract = "To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30\% had no histologic evidence ofMAC. In the remaining 70\%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.",

author = "Torriani, \{Francesca J.\} and \{Mc Cutchan\}, \{J. Allen\} and Bozzette, \{Samuel A.\} and Grafe, \{Marjorie R.\} and Havlir, \{Diane V.\}",

note = "Funding Information: Received 24 March 1994: revised 24 June 1994. Presented in part: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, 16 October 1993 (abstract 1406). Human experimentation guidelines of the US Department of Health and Human Services were followed and this work was reviewed and approved by the Institutional Review Board (School of Medicine) of the University of California, San Diego. Financial support: California Universitywide AIDS Research Program through the California Collaborative Treatment Group (CCTG): Swiss National Foundation for AIDS Research (92-7096). Reprints or correspondence: Dr. D. Havlir, UCSD Treatment Center, 2760 Fifth Ave.. Suite 300, San Diego. CA 92103. Present affiliation: Department of Pathology, University of Texas, Medical Branch, Galveston.",

year = "1994",

month = dec,

doi = "10.1093/infdis/170.6.1601",

language = "English (US)",

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AU - Grafe, Marjorie R.

AU - Havlir, Diane V.

N1 - Funding Information: Received 24 March 1994: revised 24 June 1994. Presented in part: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, 16 October 1993 (abstract 1406). Human experimentation guidelines of the US Department of Health and Human Services were followed and this work was reviewed and approved by the Institutional Review Board (School of Medicine) of the University of California, San Diego. Financial support: California Universitywide AIDS Research Program through the California Collaborative Treatment Group (CCTG): Swiss National Foundation for AIDS Research (92-7096). Reprints or correspondence: Dr. D. Havlir, UCSD Treatment Center, 2760 Fifth Ave.. Suite 300, San Diego. CA 92103. Present affiliation: Department of Pathology, University of Texas, Medical Branch, Galveston.

PY - 1994/12

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N2 - To study the pathogenesis of Mycobacterium avium complex (MAC) bacteremia, the extent of organ involvement was determined in a retrospective cohort of 44 AIDS patients with MAC bacteremia and complete autopsies between 1988 and 1992. Clinical and microbiologic histories were reviewed and lymph nodes, spleen, liver, bone marrow, small intestine, and colon from each autopsy were systematically evaluated for the presence of mycobacteria or foamy histiocytes. Of the patients, 30% had no histologic evidence ofMAC. In the remaining 70%, reticuloendothelial and gastrointestinal involvement was most common, but the number and distribution of involved sites was highly variable. The risk of developing detectable histologic involvement was related to the duration of bacteremia. In contrast to the prevailing concept, our data suggest that MAC bacteremia may precede widespread tissue disease.

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Autopsy findings in aids patients with mycobacterium avium complex bacteremia

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