TY - JOUR
T1 - Avoiding immunity and apoptosis
T2 - Manipulation of the host environment by herpes simplex virus and Epstein-Barr virus
AU - Hill, Ann B.
AU - Masucci, Maria G.
PY - 1998/4
Y1 - 1998/4
N2 - Herpesviruses infect their hosts in early life to establish latent or persistent infection with little damage to the host. They are able to reactivate throughout the life of the host and replicate to produce an infective innoculum in the face of a fully primed immune system. They achieve this lifestyle by careful manipulation of the host environment. Here we review two aspects of host defense - apoptosis of infected cells and cytotoxic T cell recognition of infected cells. We discuss avoidance of these host responses by an α-herpesvirus, herpes simplex virus, and a γ-herpesvirus, Epstein-Barr virus.
AB - Herpesviruses infect their hosts in early life to establish latent or persistent infection with little damage to the host. They are able to reactivate throughout the life of the host and replicate to produce an infective innoculum in the face of a fully primed immune system. They achieve this lifestyle by careful manipulation of the host environment. Here we review two aspects of host defense - apoptosis of infected cells and cytotoxic T cell recognition of infected cells. We discuss avoidance of these host responses by an α-herpesvirus, herpes simplex virus, and a γ-herpesvirus, Epstein-Barr virus.
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U2 - 10.1006/smvy.1997.0144
DO - 10.1006/smvy.1997.0144
M3 - Article
AN - SCOPUS:0031831341
SN - 1044-5773
VL - 8
SP - 361
EP - 368
JO - Seminars in Virology
JF - Seminars in Virology
IS - 5
ER -