B cells and their mediators as targets for therapy in solid tumors

Andrew J. Gunderson; Lisa M. Coussens

doi:10.1016/j.yexcr.2013.03.005

B cells and their mediators as targets for therapy in solid tumors

Andrew J. Gunderson
, Lisa M. Coussens

Cell Developmental and Cancer Biology

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Abstract

B cells have recently been appreciated as paracrine mediators of solid tumor development. Their ability to influence various hallmarks of cancer development, aside from antigen presentation, can be attributed to the diversity of soluble mediators they express, including cytokines and immunoglobulins, that can act directly and indirectly on the diversity of leukocyte subsets that infiltrate developing tumors, evolving neoplastic cells, as well as select T cell populations in secondary lymphoid organs and within tumor stroma. Herein, we review the literature supporting these interactions and discuss novel approaches to ameliorate protumoral B cell effects for anti-cancer therapy.

Original language	English (US)
Pages (from-to)	1644-1649
Number of pages	6
Journal	Experimental Cell Research
Volume	319
Issue number	11
DOIs	https://doi.org/10.1016/j.yexcr.2013.03.005
State	Published - Jul 1 2013

Funding

The authors thank members of the Coussens laboratory for critical discussions on content. AJG is supported by T32I078903-04 . LMC acknowledges support from the NIH/NCI, a DOD BCRP Era of Hope Scholar Expansion Award, Susan B Komen Foundation, and the Breast Cancer Research Foundation.

Funders	Funder number
Susan B. Komen Foundation
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
U.S. Department of Defense
National Institute of Health-National Cancer Institute	R01CA130980
Breast Cancer Research Foundation

Keywords

B cells
Cancer
Inflammation
Leukocytes
Myeloid cells

ASJC Scopus subject areas

Cell Biology

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10.1016/j.yexcr.2013.03.005

Cite this

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title = "B cells and their mediators as targets for therapy in solid tumors",

abstract = "B cells have recently been appreciated as paracrine mediators of solid tumor development. Their ability to influence various hallmarks of cancer development, aside from antigen presentation, can be attributed to the diversity of soluble mediators they express, including cytokines and immunoglobulins, that can act directly and indirectly on the diversity of leukocyte subsets that infiltrate developing tumors, evolving neoplastic cells, as well as select T cell populations in secondary lymphoid organs and within tumor stroma. Herein, we review the literature supporting these interactions and discuss novel approaches to ameliorate protumoral B cell effects for anti-cancer therapy.",

keywords = "B cells, Cancer, Inflammation, Leukocytes, Myeloid cells",

author = "Gunderson, \{Andrew J.\} and Coussens, \{Lisa M.\}",

note = "Funding Information: The authors thank members of the Coussens laboratory for critical discussions on content. AJG is supported by T32I078903-04 . LMC acknowledges support from the NIH/NCI, a DOD BCRP Era of Hope Scholar Expansion Award, Susan B Komen Foundation, and the Breast Cancer Research Foundation.",

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AU - Gunderson, Andrew J.

AU - Coussens, Lisa M.

N1 - Funding Information: The authors thank members of the Coussens laboratory for critical discussions on content. AJG is supported by T32I078903-04 . LMC acknowledges support from the NIH/NCI, a DOD BCRP Era of Hope Scholar Expansion Award, Susan B Komen Foundation, and the Breast Cancer Research Foundation.

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Y1 - 2013/7/1

N2 - B cells have recently been appreciated as paracrine mediators of solid tumor development. Their ability to influence various hallmarks of cancer development, aside from antigen presentation, can be attributed to the diversity of soluble mediators they express, including cytokines and immunoglobulins, that can act directly and indirectly on the diversity of leukocyte subsets that infiltrate developing tumors, evolving neoplastic cells, as well as select T cell populations in secondary lymphoid organs and within tumor stroma. Herein, we review the literature supporting these interactions and discuss novel approaches to ameliorate protumoral B cell effects for anti-cancer therapy.

AB - B cells have recently been appreciated as paracrine mediators of solid tumor development. Their ability to influence various hallmarks of cancer development, aside from antigen presentation, can be attributed to the diversity of soluble mediators they express, including cytokines and immunoglobulins, that can act directly and indirectly on the diversity of leukocyte subsets that infiltrate developing tumors, evolving neoplastic cells, as well as select T cell populations in secondary lymphoid organs and within tumor stroma. Herein, we review the literature supporting these interactions and discuss novel approaches to ameliorate protumoral B cell effects for anti-cancer therapy.

KW - B cells

KW - Cancer

KW - Inflammation

KW - Leukocytes

KW - Myeloid cells

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DO - 10.1016/j.yexcr.2013.03.005

M3 - Review article

C2 - 23499742

AN - SCOPUS:84879604267

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SP - 1644

EP - 1649

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 11

ER -

B cells and their mediators as targets for therapy in solid tumors

Abstract

Funding

Keywords

ASJC Scopus subject areas

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