TY - JOUR
T1 - B-cells in ocular adnexal lymphoproliferative lesions express B-cell attracting chemokine 1 (CXCL13)
AU - Falkenhagen, Katherine M.
AU - Braziel, Rita M.
AU - Fraunfelder, Frederick W.
AU - Smith, Justine R.
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health (EY014909), the Medical Research Foundation of Oregon and Research to Prevent Blindness (Career Development Award to J.R.S.).
PY - 2005/8
Y1 - 2005/8
N2 - PURPOSE: The homeostatic chemokine, B cell attracting chemokine 1 (CXCL13), has been implicated in the pathogenesis of lymphocyte-mediated diseases. We investigated the cellular expression of this chemokine in the spectrum of ocular adnexal lymphoproliferative lesions. DESIGN: Laboratory investigation. METHODS: CXCL13 expression in paraffin-embedded adnexal biopsy specimens was determined by indirect immunohistochemistry with antigen retrieval. RESULTS: In 15 of 16 biopsy specimens, including reactive lymphoid hyperplasia (n = 7), atypical lymphoid hyperplasia (n = 3), and B cell lymphoma (n = 6), CXCL13 was detected. CD20-positive B-cells, as well as dendritic cells and endothelial cells, expressed the chemokine. CONCLUSIONS: B-cells in ocular adnexal lymphoproliferative lesions demonstrate expression of CXCL13, a chemokine that may participate in tumor pathogenesis and is a potential target for novel therapies.
AB - PURPOSE: The homeostatic chemokine, B cell attracting chemokine 1 (CXCL13), has been implicated in the pathogenesis of lymphocyte-mediated diseases. We investigated the cellular expression of this chemokine in the spectrum of ocular adnexal lymphoproliferative lesions. DESIGN: Laboratory investigation. METHODS: CXCL13 expression in paraffin-embedded adnexal biopsy specimens was determined by indirect immunohistochemistry with antigen retrieval. RESULTS: In 15 of 16 biopsy specimens, including reactive lymphoid hyperplasia (n = 7), atypical lymphoid hyperplasia (n = 3), and B cell lymphoma (n = 6), CXCL13 was detected. CD20-positive B-cells, as well as dendritic cells and endothelial cells, expressed the chemokine. CONCLUSIONS: B-cells in ocular adnexal lymphoproliferative lesions demonstrate expression of CXCL13, a chemokine that may participate in tumor pathogenesis and is a potential target for novel therapies.
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U2 - 10.1016/j.ajo.2005.02.026
DO - 10.1016/j.ajo.2005.02.026
M3 - Article
C2 - 16086967
AN - SCOPUS:23744456876
SN - 0002-9394
VL - 140
SP - 335
EP - 337
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 2
ER -