Barbiturate dependence in mice: Effects of continuous vs. Discontinuous drug administration

J. K. Belknap, G. Ondrusek, J. Berg, S. Waddingham

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Three groups of DBA/2J mice were continuously exposed for 3, 6 or 9 days to a milled diet containing phenobarbital. Two additional groups were given a discontinuous drug administration schedule with either one or two 24 h drug-free periods interpolated among the 6 or 9 days of phenobarbital consumption, respectively. The discontinuous schedule of drug administration significantly attenuated the development of physical dependence as determined by the severity of withdrawal symptoms. Functional tolerance development was also attenuated in a manner that closely paralleled the effects on physical dependence development. The 5 group means showed a perfect rank order correlation between functional tolerance and physical dependence development.

Original languageEnglish (US)
Pages (from-to)195-198
Number of pages4
Issue number2
StatePublished - Jan 1977
Externally publishedYes


  • Barbiturate physical dependence
  • Functional tolerance
  • Withdrawal symptoms

ASJC Scopus subject areas

  • Pharmacology


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