Barbiturate dependence in mice: Evidence for β-adrenergic receptor proliferation in brain

S. Waddingham; W. R. Riffee; J. K. Belknap; J. R. Sheppard

Barbiturate dependence in mice: Evidence for β-adrenergic receptor proliferation in brain

S. Waddingham, W. R. Riffee, J. K. Belknap, J. R. Sheppard

Research output: Contribution to journal › Article › peer-review

Abstract

C57BL/6J and DBA/2J inbred mice were assayed for β-adrenergic receptor density following 7 days of chronic phenobarbital intoxication. These physically dependent mice showed a greater brain receptor density than did the control, while acute intoxication to phenobarbital produced no significant effects. C57BL/6J mice showed a higher average receptor density than did the DBA/2J mice under all conditions. These findings support the hypothesis that chronic barbiturate intoxication leads to a receptor supersensitivity which may play a role in the phenomena of functional tolerance and physical dependence.

Original language	English (US)
Pages (from-to)	207-220
Number of pages	14
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	20
Issue number	2
State	Published - 1978
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Barbiturate dependence in mice: Evidence for β-adrenergic receptor proliferation in brain",

abstract = "C57BL/6J and DBA/2J inbred mice were assayed for β-adrenergic receptor density following 7 days of chronic phenobarbital intoxication. These physically dependent mice showed a greater brain receptor density than did the control, while acute intoxication to phenobarbital produced no significant effects. C57BL/6J mice showed a higher average receptor density than did the DBA/2J mice under all conditions. These findings support the hypothesis that chronic barbiturate intoxication leads to a receptor supersensitivity which may play a role in the phenomena of functional tolerance and physical dependence.",

author = "S. Waddingham and Riffee, {W. R.} and Belknap, {J. K.} and Sheppard, {J. R.}",

year = "1978",

language = "English (US)",

volume = "20",

pages = "207--220",

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T2 - Evidence for β-adrenergic receptor proliferation in brain

AU - Waddingham, S.

AU - Riffee, W. R.

AU - Belknap, J. K.

AU - Sheppard, J. R.

PY - 1978

Y1 - 1978

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AB - C57BL/6J and DBA/2J inbred mice were assayed for β-adrenergic receptor density following 7 days of chronic phenobarbital intoxication. These physically dependent mice showed a greater brain receptor density than did the control, while acute intoxication to phenobarbital produced no significant effects. C57BL/6J mice showed a higher average receptor density than did the DBA/2J mice under all conditions. These findings support the hypothesis that chronic barbiturate intoxication leads to a receptor supersensitivity which may play a role in the phenomena of functional tolerance and physical dependence.

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JF - Research Communications in Chemical Pathology and Pharmacology

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ER -

Barbiturate dependence in mice: Evidence for β-adrenergic receptor proliferation in brain

Abstract

ASJC Scopus subject areas

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