Barrett's esophagus: Incidence, etiology, pathophysiology, prevention and treatment

Nir Modiano, Lauren B. Gerson

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Barrett's esophagus is a metaplastic alteration of the normal esophageal epithelium that is detected on endoscopic examination and pathologically confirmed by the presence of intestinal metaplasia on biopsy. Its major significance is as a predisposing factor for esophageal adenocarcinoma, which carries a high mortality rate and a rapidly growing incidence in the United States. Detection of Barrett's esophagus allows for endoscopic surveillance in order to detect the potential development of dysplasia and early cancer before symptoms develop, and thereby significantly increases treatment options and may lower mortality from esophageal adenocarcinoma. Much current work in the field is aimed at reducing the risk of progression from Barrett's esophagus to cancer, and in the identification of biomarkers that may predict progression towards cancer. Barrett's esophagus is present in 10%-20% of patients with gastroesophageal reflux disease (GERD) and has also been detected in patients who deny classic GERD symptoms and are undergoing endoscopy for other indications. We used an evidence-based approach to describe treatment options for patients with Barrett's esophagus.

Original languageEnglish (US)
Pages (from-to)1035-1045
Number of pages11
JournalTherapeutics and Clinical Risk Management
Issue number6
StatePublished - 2007
Externally publishedYes


  • Barrett's esophagus
  • Endoscopic surveillance
  • Esophageal adenocarcinoma
  • Evidence-based approach

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)
  • Chemical Health and Safety
  • Safety Research


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